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International Journal of Hypertension
Volume 2011, Article ID 318549, 8 pages
Review Article

Benefits from Treatment and Control of Patients with Resistant Hypertension

1Veterans Affairs Medical Center, George Washington University, Washington, DC 20422, USA
2Veterans Affairs Medical Center, Georgetown University, Washington, DC 20422, USA
32nd Propaedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, 49 Konstantinoupoleos Street, 54643 Thessaloniki, Greece

Received 11 October 2010; Accepted 16 November 2010

Academic Editor: A. Gradman

Copyright © 2011 Michael Doumas et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Resistant hypertension is commonly found in everyday clinical practice. However, the risks of resistant hypertension, as well as the benefits of treatment and control of blood pressure in patients with resistant hypertension remain vaguely clarified. Data from small clinical studies and observational cohorts suggest that patients with resistant hypertension are at increased cardiovascular risk, while control of blood pressure offers substantial benefits. It has to be noted however that data from appropriate large randomized studies are missing, and resistant hypertension remains remarkably understudied. Resistant hypertension has attracted significant scientific interest lately, as new therapeutic modalities become available. The interventional management of resistant hypertension either by carotid baroreceptor stimulation or renal sympathetic denervation is currently under investigation with promising preliminary results. This review presents available evidence regarding the benefits of treatment and control of blood pressure in patients with resistant hypertension and offers a critical evaluation of existing data in this field.