Arginase Inhibitor in the Pharmacological Correction of Endothelial Dysfunction

Table 2

Influence of methionine and L-norvaline on indicators of haemodynamics and coefficient of endothelial dysfunction in modeling of the homocysteine-induced NO deficiency (M ± m, n = 10).

Groups of animals	Functional tests	SAP, mm hg	DAP, mm hg	Area of vascular reaction	CED
Tween-80	Before test	129,2 ± 4,3	82,4 ± 5,9		0,9 ± 0,2
	AH	74,1 ± 2,9	39,4 ± 3,1	1124,2 ± 63,7
	NP	67,2 ± 5,1	42,9 ± 5,4	1011,8 ± 94,6
Methionine 3 g/kg	Before test	118,9 ± 10,1	76,6 ± 7,2		3,3 ± 0,3*
	AH	80,1 ± 2,9	41,4 ± 2,3	854,6 ± 61,4*
	NP	72,3 ± 6,7	45,9 ± 4,3	2820,2 ± 210,4*
Methionine 3 g/kg + L-norvaline 10 mg/kg	Before test	129,4 ± 2,8**	72,6 ± 5,4**		1,4 ± 0,1**
	AH	91,0 ± 3,1	47,1 ± 1,8**	920,9 ± 7,8*
	NP	123,8 ± 4,5	63,4 ± 5,0**	1214,7 ± 128,4**

* 𝑃<.05 in comparison with intact group of animals; **𝑃<.05 in comparison with metionine group.