Research Article
TRC120038, a Novel Dual AT1/ETA Receptor Blocker for Control of Hypertension, Diabetic Nephropathy, and Cardiomyopathy in ob-ZSF1 Rats
Table 1
Terminal left ventricular functional parameters of male ob-ZSF1 rats treated with vehicle, TRC120038, or candesartan.
| | Left Ventricular functional Parameters | Vehicle 1 mL/kg | TRC120038 11.8 mg/kg, bid, po | Candesartan 0.3 mg/kg, od, po | | Mean ± SEM () | Mean ± SEM () | Mean ± SEM () |
| | Heart rate (bpm) | | | | | Minimum volume (L) | | | | | End systolic volume (L) | | | | | End diastolic volume (L) | | | | | End systolic pressure (mmHg) | | | | | End diastolic pressure (mmHg) | | | | | Stroke volume (L) | | | | | Ejection fraction (%) | | | | | Cardiac output (L/min) | | | | | Arterial elastance (mmHg/L) | | | | | Tau_w (msec) | | | | | Total peripheral resistance index | | | | | Augmentation Index | | | |
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versus vehicle; versus candesartan by Student’s -test.
Data represent mean ± SEM (standard error mean).
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