Table of Contents Author Guidelines Submit a Manuscript
International Journal of Hypertension
Volume 2012 (2012), Article ID 147321, 9 pages
http://dx.doi.org/10.1155/2012/147321
Clinical Study

Consumption of High-Polyphenol Dark Chocolate Improves Endothelial Function in Individuals with Stage 1 Hypertension and Excess Body Weight

1Discipline of Clinical and Experimental Pathophysiology, Rio de Janeiro State University, 20551-030 Rio de Janeiro, RJ, Brazil
2Department of Applied Nutrition, Nutrition Institute, Rio de Janeiro State University, 20551-030 Rio de Janeiro, RJ, Brazil
3Lipids Laboratory, Rio de Janeiro State University, 20551-030 Rio de Janeiro, RJ, Brazil

Received 3 August 2012; Accepted 28 September 2012

Academic Editor: Mario Fritsch Neves

Copyright © 2012 Lívia de Paula Nogueira et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [23 citations]

The following is the list of published articles that have cited the current article.

  • Grace Farhat, Sandra Drummond, Lorna Fyfe, and E. A. S. Al-Dujaili, “Dark Chocolate: An Obesity Paradox or a Culprit for Weight Gain?,” Phytotherapy Research, 2013. View at Publisher · View at Google Scholar
  • Jennifer B. Keogh, and Peter M. Clifton, “Vitamin D and cardiovascular health,” Current Opinion in Lipidology, vol. 24, no. 2, pp. 183–184, 2013. View at Publisher · View at Google Scholar
  • Andrew B. Petrone, J. Michael Gaziano, and Luc Djoussé, “Effects of Dark Chocolate and Cocoa Products on Endothelial Function: A Meta-Analysis,” Current Nutrition Reports, 2013. View at Publisher · View at Google Scholar
  • Luc Bruyndonckx, Vicky Y. Hoymans, Amaryllis H. Van Craenenbroeck, Dirk K. Vissers, Christiaan J. Vrints, José Ramet, and Viviane M. Conraads, “Assessment of Endothelial Dysfunction in Childhood Obesity and Clinical Use,” Oxidative Medicine and Cellular Longevity, vol. 2013, pp. 1–19, 2013. View at Publisher · View at Google Scholar
  • Zahra Bahadoran, Parvin Mirmiran, and Fereidoun Azizi, “Dietary polyphenols as potential nutraceuticals in management of diabetes: a review,” Journal of Diabetes & Metabolic Disorders, vol. 12, no. 1, pp. 43, 2013. View at Publisher · View at Google Scholar
  • Paulo Zielinsky, Luiz Henrique Nicoloso, Izabele Vian, Alexandre Antonio Naujorks, Mauro Lopes, Caroline Klein, Ana Maria Zilio, Stefano Busato, Antonio Luiz Piccoli, and Carolina Weiss Barbisan, “Maternal Restriction of Polyphenols and Fetal Ductal Dynamics in Normal Pregnancy: An Open Clinical Trial,” Arquivos Brasileiros De Cardiologia, vol. 101, no. 3, pp. 217–225, 2013. View at Publisher · View at Google Scholar
  • I. Ibero-Baraibar, I. Abete, S. Navas-Carretero, A. Massis-Zaid, J. A. Martinez, and M. A. Zulet, “Oxidised LDL levels decreases after the consumption of ready-to-eat meals supplemented with cocoa extract within a hypocaloric diet,” Nutrition Metabolism and Cardiovascular Diseases, vol. 24, no. 4, pp. 416–422, 2014. View at Publisher · View at Google Scholar
  • Nasiruddin Khan, Olha Khymenets, Mireia Urpí-Sardà, Sara Tulipani, Mar Garcia-Aloy, María Monagas, Ximena Mora-Cubillos, Rafael Llorach, and Cristina Andres-Lacueva, “Cocoa Polyphenols and Inflammatory Markers of Cardiovascular Disease,” Nutrients, vol. 6, no. 2, pp. 844–880, 2014. View at Publisher · View at Google Scholar
  • Dagmar Fuchs, Young de Graaf, Roeland van Kerckhoven, and Richard Draijer, “Effect of Tea Theaflavins and Catechins on Microvascular Function,” Nutrients, vol. 6, no. 12, pp. 5772–5785, 2014. View at Publisher · View at Google Scholar
  • Diana Gonzalez-Pena, Javier Angulo, Susana Vallejo, Clara Colina-Coca, Begona de Ancos, Carlos F. Sanchez-Ferrer, Concepcion Peiro, and Concepcion Sanchez-Moreno, “High-cholesterol diet enriched with onion affects endothelium-dependent relaxation and NADPH oxidase activity in mesenteric microvessels from Wistar r,” Nutrition & Metabolism, vol. 11, 2014. View at Publisher · View at Google Scholar
  • Morten Hedetoft, and Niels Vidiendal Olsen, “Evaluation of endothelial function by peripheral arterial tonometry and relation with the nitric oxide pathway,” Nitric Oxide - Biology and Chemistry, vol. 42, pp. 1–8, 2014. View at Publisher · View at Google Scholar
  • Rosario D’Anna, Angelo Santamaria, Maria Letizia Cannata, Maria Lieta Interdonato, Grazia Maria Giorgianni, Roberta Granese, Francesco Corrado, and Alessandra Bitto, “Effects of a New Flavonoid and Myo-Inositol Supplement on Some Biomarkers of Cardiovascular Risk in Postmenopausal Women: A Randomized Trial,” International Journal of Endocrinology, vol. 2014, pp. 1–7, 2014. View at Publisher · View at Google Scholar
  • Joao Tomé-Carneiro, and Francesco Visioli, “Polyphenol-based nutraceuticals for the prevention and treatment of cardiovascular disease: Review of human evidence,” Phytomedicine, 2015. View at Publisher · View at Google Scholar
  • Jaime L. Clark, Peter Zahradka, and Carla G. Taylor, “Efficacy of flavonoids in the management of high blood pressure,” Nutrition Reviews, pp. nuv048, 2015. View at Publisher · View at Google Scholar
  • Marco Valussi, and Clara Minto, “Cacao as a globalised functional food: Review on cardiovascular effects of chocolate consumption,” Open Agriculture Journal, vol. 10, pp. 36–51, 2016. View at Publisher · View at Google Scholar
  • Grazia Borrelli, and Daniela Trono, “Molecular Approaches to Genetically Improve the Accumulation of Health-Promoting Secondary Metabolites in Staple Crops—A Case Study: The Lipoxygenase-B1 Genes and Regulation of the Carotenoid Content in Pasta Products,” International Journal of Molecular Sciences, vol. 17, no. 7, pp. 1177, 2016. View at Publisher · View at Google Scholar
  • Sarah Lau, Ekavi Georgousopoulou, Jane Kellett, Jackson Thomas, Andrew McKune, Duane Mellor, Paul Roach, and Nenad Naumovski, “The Effect of Dietary Supplementation of Green Tea Catechins on Cardiovascular Disease Risk Markers in Humans: A Systematic Review of Clinical Trials,” Beverages, vol. 2, no. 2, pp. 16, 2016. View at Publisher · View at Google Scholar
  • Sandra Fernández-Vallinas, Marta Miguel, and Amaya Aleixandre, “Long-term antihypertensive effect of a soluble cocoa fiber product in spontaneously hypertensive rats,” Food & Nutrition Research, vol. 60, no. 0, 2016. View at Publisher · View at Google Scholar
  • Cristian Del Bo’, Valeria Deon, Marisa Porrini, Jonica Campolo, Marina Parolini, and Patrizia Riso, “Intra- and interday repeatability of peripheral arterial function: suitability and potential limitations,” Microcirculation, vol. 23, no. 7, pp. 503–511, 2016. View at Publisher · View at Google Scholar
  • Nina Ayoobi, Sima Jafarirad, Mohammad Hossein Haghighizadeh, and Alireza Jahanshahi, “Protective effect of dark chocolate on cardiovascular disease factors and body composition in type 2 diabetes: A parallel, randomized, clinical trial,” Iranian Red Crescent Medical Journal, vol. 19, no. 8, 2017. View at Publisher · View at Google Scholar
  • Bozena Sosnowska, Peter Penson, and Maciej Banach, “The role of nutraceuticals in the prevention of cardiovascular disease,” Cardiovascular Diagnosis and Therapy, vol. 7, pp. S21–S31, 2017. View at Publisher · View at Google Scholar
  • Celia Rodríguez-Pérez, Antonio Segura-Carretero, and María del Mar Contreras, “Phenolic compounds as natural and multifunctional anti-obesity agents: A review,” Critical Reviews in Food Science and Nutrition, pp. 1–18, 2017. View at Publisher · View at Google Scholar
  • Diana Oliveira, and Anne Nilsson, “Effects of dark-chocolate on appetite variables and glucose tolerance: A 4 week randomised crossover intervention in healthy middle aged subjects,” Journal of Functional Foods, vol. 37, pp. 390–399, 2017. View at Publisher · View at Google Scholar