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International Journal of Hypertension
Volume 2012, Article ID 178078, 6 pages
http://dx.doi.org/10.1155/2012/178078
Clinical Study

Ambulatory Arterial Stiffness Index Is Higher in Hypertensive Patients with Chronic Kidney Disease

1Department of Clinical Medicine, Rio de Janeiro State University, Rio de Janeiro, RJ, Brazil
2Departamento de Clínica Médica, Hospital Universitario Pedro Ernesto, Avenue 28 de Setembro 77, Sala 329, Vila Isabel, 20551-030 Rio de Janeiro, RJ, Brazil
3Nephrology Division, Rio de Janeiro State University, Rio de Janeiro, RJ, Brazil

Received 7 January 2012; Revised 28 February 2012; Accepted 28 February 2012

Academic Editor: Agostino Virdis

Copyright © 2012 Ronaldo Altenburg Gismondi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Ambulatory arterial stiffness index (AASI) is a parameter obtained from ambulatory blood pressure monitoring (ABPM) that correlates with clinical endpoints. The aim of this study was to compare AASI in nondiabetic hypertensive patients with and without chronic kidney disease (CKD). Subjects with systemic arterial hypertension (SAH, ) with normal renal function, aged 40 to 75 years, were compared to hypertensive patients with CKD ( ) presenting estimated glomerular filtration rate (eGFR) <60 mL/min by MDRD formula. ABPM was carried out in all patients. In CKD group, eGFR was 35.3 ± 2.8 ml/min. The mean 24-hour systolic and diastolic blood pressure (BP) was similar in both groups. AASI was significantly higher in CKD group ( versus , ), positively correlated to age ( , ) and pulse pressure ( , ) and negatively correlated to nocturnal BP fall ( , ). These findings indicate the presence of stiffer vessels in CKD hypertensive patients.