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International Journal of Hypertension
Volume 2012 (2012), Article ID 187526, 6 pages
http://dx.doi.org/10.1155/2012/187526
Review Article

Vascular Dysfunction as Target Organ Damage in Animal Models of Hypertension

1Department of Clinical Medicine, State University of Rio de Janeiro, Avenue 28 de Setembro, 77 sala 329, 20551-030 Rio de Janeiro, RJ, Brazil
2Faculty of Nutrition, Federal University of Rio de Janeiro, Rua Mariz e Barros 775, 20270-004 Rio de Janeiro, RJ, Brazil

Received 15 September 2011; Accepted 29 November 2011

Academic Editor: Agostino Virdis

Copyright © 2012 Mario Fritsch Neves et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. P. M. Kearney, M. Whelton, K. Reynolds, P. Muntner, P. K. Whelton, and J. He, “Global burden of hypertension: analysis of worldwide data,” The Lancet, vol. 365, no. 9455, pp. 217–223, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  2. U. Landmesser and H. Drexler, “Endothelial function and hypertension,” Current Opinion in Cardiology, vol. 22, no. 4, pp. 316–320, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  3. N. Peled, D. Shitrit, B. D. Fox et al., “Peripheral arterial stiffness and endothelial dysfunction in idiopathic and scleroderma associated pulmonary arterial hypertension,” Journal of Rheumatology, vol. 36, no. 5, pp. 970–975, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  4. A. Virdis, L. Ghiadoni, D. Versari, C. Giannarelli, A. Salvetti, and S. Taddei, “Endothelial function assessment in complicated hypertension,” Current Pharmaceutical Design, vol. 14, no. 18, pp. 1761–1770, 2008. View at Publisher · View at Google Scholar · View at Scopus
  5. D. Versari, E. Daghini, A. Virdis, L. Ghiadoni, and S. Taddei, “Endothelial dysfunction as a target for prevention of cardiovascular disease,” Diabetes Care, vol. 32, pp. S314–S321, 2009. View at Google Scholar · View at Scopus
  6. W. T. Wong, S. L. Wong, X. Y. Tian, and Y. Huang, “Endothelial dysfunction: the common consequence in diabetes and hypertension,” Journal of Cardiovascular Pharmacology, vol. 55, no. 4, pp. 300–307, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. S. Taddei, A. Virdis, L. Ghiadoni, A. Magagna, and A. Salvetti, “Vitamin C improves endothelium-dependent vasodilation by restoring nitric oxide activity in essential hypertension,” Circulation, vol. 97, no. 22, pp. 2222–2229, 1998. View at Google Scholar · View at Scopus
  8. E. L. Schiffrin, “Role of endothelin-1 in hypertension,” Hypertension, vol. 34, no. 4, part 2, pp. 876–881, 1999. View at Google Scholar · View at Scopus
  9. L. Ghiadoni, S. Taddei, A. Virdis et al., “Endothelial function and common carotid artery wall thickening in patients with essential hypertension,” Hypertension, vol. 32, no. 1, pp. 25–32, 1998. View at Google Scholar · View at Scopus
  10. S. Taddei and A. Salvetti, “Endothelial dysfunction in essential hypertension: clinical implications,” Journal of Hypertension, vol. 20, no. 9, pp. 1671–1674, 2002. View at Publisher · View at Google Scholar · View at Scopus
  11. M. J. Mulvany and C. Aalkjaer, “Structure and function of small arteries,” Physiological Reviews, vol. 70, no. 4, pp. 921–961, 1990. View at Google Scholar · View at Scopus
  12. J. Pfitzner, “Poiseuille and his law,” Anaesthesia, vol. 31, no. 2, pp. 273–275, 1976. View at Google Scholar · View at Scopus
  13. H. D. Intengan and E. L. Schiffrin, “Structure and mechanical properties of resistance arteries in hypertension: role of adhesion molecules and extracellular matrix determinants,” Hypertension, vol. 36, no. 3, pp. 312–318, 2000. View at Google Scholar · View at Scopus
  14. H. D. Intengan, G. Thibault, J. S. Li, and E. L. Schiffrin, “Resistance artery mechanics, structure, and extracellular components in spontaneously hypertensive rats: effects of angiotensin receptor antagonism and converting enzyme inhibition,” Circulation, vol. 100, no. 22, pp. 2267–2275, 1999. View at Google Scholar · View at Scopus
  15. H. D. Intengan and E. L. Schiffrin, “Vascular remodeling in hypertension: roles of apoptosis, inflammation, and fibrosis,” Hypertension, vol. 38, no. 3, pp. 581–587, 2001. View at Google Scholar · View at Scopus
  16. M. F. Neves, A. Virdis, and E. L. Schiffrin, “Resistance artery mechanics and composition in angiotensin II-infused rats: effects of aldosterone antagonism,” Journal of Hypertension, vol. 21, no. 1, pp. 189–198, 2003. View at Publisher · View at Google Scholar · View at Scopus
  17. P. M. Vanhoutte, “Endothelium-derived relaxing and contracting factors,” Advances in Nephrology from the Necker Hospital, vol. 19, pp. 3–16, 1990. View at Google Scholar · View at Scopus
  18. D. H. Endemann and E. L. Schiffrin, “Endothelial dysfunction,” Journal of the American Society of Nephrology, vol. 15, no. 8, pp. 1983–1992, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  19. S. Verma, C. H. Wang, S. H. Li et al., “A self-fulfilling prophecy: c-reactive protein attenuates nitric oxide production and inhibits angiogenesis,” Circulation, vol. 106, no. 8, pp. 913–919, 2002. View at Publisher · View at Google Scholar · View at Scopus
  20. K. K. Griendling and G. A. FitzGerald, “Oxidative stress and cardiovascular injury: part I: basic mechanisms and in vivo monitoring of ROS,” Circulation, vol. 108, no. 16, pp. 1912–1916, 2003. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  21. C. A. Hamilton, M. J. Brosnan, S. Al-Benna, G. Berg, and A. F. Dominiczak, “NAD(P)H oxidase inhibition improves endothelial function in rat and human blood vessels,” Hypertension, vol. 40, no. 5, pp. 755–762, 2002. View at Publisher · View at Google Scholar · View at Scopus
  22. R. M. Touyz, X. Chen, F. Tabet et al., “Expression of a functionally active gp91phox-containing neutrophil-type NAD(P)H oxidase in smooth muscle cells from human resistance arteries: regulation by angiotensin II,” Circulation Research, vol. 90, no. 11, pp. 1205–1213, 2002. View at Publisher · View at Google Scholar · View at Scopus
  23. A. Virdis, M. F. Neves, F. Amiri, E. Viel, R. M. Touyz, and E. L. Schiffrin, “Spironolactone improves angiotensin-induced vascular changes and oxidative stress,” Hypertension, vol. 40, no. 4, pp. 504–510, 2002. View at Publisher · View at Google Scholar · View at Scopus
  24. A. Virdis, M. Iglarz, M. F. Neves et al., “Effect of hyperhomocystinemia and hypertension on endothelial function in methylenetetrahydrofolate reductase-deficient mice,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 23, no. 8, pp. 1352–1357, 2003. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  25. M. F. Neves, D. Endemann, F. Amiri et al., “Small artery mechanics in hyperhomocysteinemic mice: effects of angiostensin II,” Journal of Hypertension, vol. 22, no. 5, pp. 959–966, 2004. View at Publisher · View at Google Scholar · View at Scopus
  26. J. Deanfield, A. Donald, C. Ferri et al., “Endothelial function and dysfunction. Part I: methodological issues for assessment in the different vascular beds: a statement by the working group on endothelin and endothelial factors of the European society of hypertension,” Journal of Hypertension, vol. 23, no. 1, pp. 7–17, 2005. View at Publisher · View at Google Scholar · View at Scopus
  27. F. Feihl, L. Liaudet, and B. Waeber, “The macrocirculation and microcirculation of hypertension,” Current Hypertension Reports, vol. 11, no. 3, pp. 182–189, 2009. View at Publisher · View at Google Scholar · View at Scopus
  28. B. I. Levy, G. Ambrosio, A. R. Pries, and H. A. J. Struijker-Boudier, “Microcirculation in hypertension: a new target for treatment?” Circulation, vol. 104, no. 6, pp. 735–740, 2001. View at Google Scholar · View at Scopus
  29. M. E. Safar and P. Lacolley, “Disturbance of macro- and microcirculation: relations with pulse pressure and cardiac organ damage,” American Journal of Physiology, vol. 293, no. 1, pp. H1–H7, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  30. H. A. J. Struijker Boudier, G. M. S. Cohuet, M. Baumann, and M. E. Safar, “The heart, macrocirculation and microcirculation in hypertension: a unifying hypothesis,” Journal of Hypertension, Supplement, vol. 21, no. 3, pp. S19–S23, 2003. View at Google Scholar · View at Scopus
  31. D. R. Witte, Y. van der Graaf, D. E. Grobbee, and M. L. Bots, “Measurement of flow-mediated dilatation of the brachial artery is affected by local elastic vessel wall properties in high-risk patients,” Atherosclerosis, vol. 182, no. 2, pp. 323–330, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  32. L. Parvathaneni, J. Harp, A. Zelinger, and M. A. Silver, “Relation between brachial artery reactivity and noninvasive large and small arterial compliance in healthy volunteers,” American Journal of Cardiology, vol. 89, no. 7, pp. 894–895, 2002. View at Publisher · View at Google Scholar · View at Scopus
  33. C. I. Wright, H. J. Scholten, J. C. M. Schilder et al., “Arterial stiffness, endothelial function and microcirculatory reactivity in healthy young males,” Clinical Physiology and Functional Imaging, vol. 28, no. 5, pp. 299–306, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  34. N. K. Hsieh, J. Y. Wang, J. C. Liu, S. D. Wang, and H. I. Chen, “Nitric oxide inhibition accelerates hypertension and induces perivascular inflammation in rats,” Clinical and Experimental Pharmacology and Physiology, vol. 31, no. 4, pp. 212–218, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  35. K. P. Patel, Y. F. Li, and Y. Hirooka, “Role of nitric oxide in central sympathetic outflow,” Experimental Biology and Medicine, vol. 226, no. 9, pp. 814–824, 2001. View at Google Scholar · View at Scopus
  36. L. Paulis, J. Zicha, J. Kunes et al., “Regression of L-NAME-induced hypertension: the role of nitric oxide and endothelium-derived constricting factor,” Hypertension Research, vol. 31, no. 4, pp. 793–803, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  37. A. Špániková, P. Šimončíková, T. Ravingerová, O. Pecháňová, and M. Barančík, “The effect of chronic nitric oxide synthases inhibition on regulatory proteins in rat hearts,” Molecular and Cellular Biochemistry, vol. 312, no. 1-2, pp. 113–120, 2008. View at Publisher · View at Google Scholar · View at PubMed
  38. J. Török, R. Koprdová, M. Cebová, J. Kuneš, and F. Kristek, “Functional and structural pattern of arterial responses in hereditary hypertriglyceridemic and spontaneously hypertensive rats in early stage of experimental hypertension,” Physiological Research, vol. 55, supplement, pp. S65–S71, 2006. View at Google Scholar
  39. I. Bernatova, Z. Csizmadiova, J. Kopincova, and A. Puzserova, “Vascular function and nitric oxide production in chronic social-stress-exposed rats with various family history of hypertension,” Journal of Physiology and Pharmacology, vol. 58, no. 3, pp. 487–501, 2007. View at Google Scholar
  40. V. M. Campese, Y. Shaohua, and Z. Huiquin, “Oxidative stress mediates angiotensin II-dependent stimulation of sympathetic nerve activity,” Hypertension, vol. 46, no. 3, pp. 533–539, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  41. S. Hojná, M. Kadlecová, Z. Dobešová, V. Valoušková, J. Zicha, and J. Kuneš, “The participation of brain NO synthase in blood pressure control of adult spontaneously hypertensive rats,” Molecular and Cellular Biochemistry, vol. 297, no. 1-2, pp. 21–29, 2007. View at Publisher · View at Google Scholar · View at PubMed
  42. J. Török and F. Kristek, “Functional and morphological pattern of vascular responses in two models of experimental hypertension,” Experimental and Clinical Cardiology, vol. 6, no. 3, pp. 142–148, 2001. View at Google Scholar · View at Scopus
  43. K. Nakanishi, N. Hara, and Y. Nagai, “Salt-sensitive hypertension in conscious rats induced by chronic nitric oxide blockade,” American Journal of Hypertension, vol. 15, no. 2, pp. 150–156, 2002. View at Publisher · View at Google Scholar · View at Scopus
  44. D. S. A. Majid and L. Kopkan, “Nitric oxide and superoxide interactions in the kidney and their implication in the development of salt-sensitive hypertension,” Clinical and Experimental Pharmacology and Physiology, vol. 34, no. 9, pp. 946–952, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus