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International Journal of Hypertension
Volume 2012, Article ID 257501, 6 pages
Clinical Study

Evaluation of Clinical Variables Associated with Increased Carotid Intima-Media Thickness in Middle-Aged Hypertensive Women

1Department of Clinical Medicine, State University of Rio de Janeiro, Rua Vinte e Oito de Setembro, 77, Sala 329—Vila Isabel, 20551-030—Rio de Janeiro, RJ, Brazil
2Institution of Nutrition, State University of Rio de Janeiro, Rua Vinte e Oito de Setembro, 77, Sala 329, Vila Isabel, 20551-030 Rio de Janeiro, RJ, Brazil

Received 3 February 2012; Accepted 9 April 2012

Academic Editor: Agostino Virdis

Copyright © 2012 Michelle Trindade et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


It has been previously documented that carotid intima-media thickness (cIMT) is a predictor of cardiovascular disease. The aim of this study was to identify clinical parameters associated with an increased cIMT treated hypertensive women. Female patients ( ) with essential hypertension, aged 40–65 years, were included in this study. Vascular ultrasound was performed and the patients were divided into two groups according to the values of cIMT (< or ≥0.9 mm). Patients with greater cIMT presented significantly higher systolic blood pressure and pulse pressure. Serum HDL-cholesterol was significantly lower and CRP was significantly higher in the same group. There was a significant correlation between cIMT and age ( , ), systolic blood pressure ( , ), pulse pressure ( , ), and LDL-cholesterol ( , ). cIMT was correlated to CRP ( , ) and negatively correlated to HDL-cholesterol ( , ). In logistic regression, only HDL-cholesterol, CRP, and pulse pressure were shown to be independent variables associated to increased cIMT. In conclusion, pulse pressure, HDL-cholesterol, and CRP are variables correlated with cIMT in treated hypertensive women.