Influence of Angiotensin II Subtype 2 Receptor (AT₂R) Antagonist, PD123319, on Cardiovascular Remodelling of Aged Spontaneously Hypertensive Rats during Chronic Angiotensin II Subtype 1 Receptor (AT₁R) Blockade

Figure 3

Representative light micrographs of cardiac (a–e) perivascular and (f–j) interstitial fibrosis in senescent SHRs treated with (a, f) vehicle (control), (b, g) candesartan cilexetil (2 mg/kg/day), (c, h) candesartan cilexetil in combination with PD123319 (10 mg/kg/day), (d, i) PD123319 alone, or (e, j) hydralazine (30 mg/kg/day). Scale bar = 50 μm.

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