Influence of Angiotensin II Subtype 2 Receptor (R) Antagonist, PD123319, on Cardiovascular Remodelling of Aged Spontaneously Hypertensive Rats during Chronic Angiotensin II Subtype 1 Receptor (R) Blockade
Figure 5
(a) Perivascular fibrosis of adult SHRs treated with vehicle (control, ), candesartan cilexetil (2 mg/kg/day) alone () or in combination with PD123319 (10 mg/kg/day, ), or PD123319 alone (). (b) Perivascular fibrosis of senescent SHRs treated with vehicle (control, ), candesartan cilexetil alone () or in combination with PD123319 (), PD123319 alone (), or hydralazine (30 mg/kg/day, ). Perivascular fibrosis of intramyocardial arterioles, calculated as cross-sectional area of adventitia to lumen ratio. * versus control (1-way ANOVA).
