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International Journal of Hypertension
Volume 2012, Article ID 581780, 9 pages
Clinical Study

N-Domain Isoform of Angiotensin I Converting Enzyme as a Marker of Hypertension: Populational Study

1Nephrology Division, Department of Medicine, Federal University of Sao Paulo, 740 Botucatu Street, 04023-900 Sao Paulo, SP, Brazil
2Laboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), Sao Paulo University Medical School, 05403-900 Sao Paulo, SP, Brazil
3Department of Physiological Sciences, Federal University of Espirito Santo, 29075-910 Vitoria, ES, Brazil

Received 4 February 2012; Accepted 5 March 2012

Academic Editor: Kazuko Masuo

Copyright © 2012 Leila C. V. Maluf-Meiken et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The aim of this paper was to investigate the presence of the urinary 90 kDa N-domain ACE in a cohort of the population from Vitoria, Brazil, to verify its association with essential hypertension since this isoform could be a possible genetic marker of hypertension. Anthropometric, clinical, and laboratory parameters of the individuals were evaluated ( ) and the blood pressure (BP) was measured. The study population was divided according to ACE isoforms in urine as follows: ACE 65/90/190, presence of three ACE isoforms ( ), ACE 90+ (65/90) ( ), and ACE 90 (65/190) ( ) based on the presence (+) or absence (−) of the 90 kDa ACE isoform. The anthropometric parameters, lipid profile, serum levels of uric acid, glucose, and the systolic and diastolic BP were significantly greater in the ACE 90+ compared with the ACE 90 and ACE 65/90/190 individuals. We found that 98% of individuals from the ACE 90+ group and 38% from the ACE 65/90/190 group had hypertension, compared to only 1% hypertensive individuals in the ACE 90 group. There is a high presence of the 90 kDa N-domain ACE isoform (85%) in the studied population. The percentile of normotensive subjects with three isoforms was 62%. Our findings could contribute to the development of new efficient strategy to prevent and treat hypertension to avoid the development of cardiovascular disease.