Apo A1 Mimetic Rescues the Diabetic Phenotype of HO-2 Knockout Mice via an Increase in HO-1 Adiponectin and LKBI Signaling Pathway

Figure 3

Effect of L-4F on redox status, HO-1 levels, and activity in HO-2 null mice. (a) Levels of superoxide produced in WT, HO-2^(−/−) and L-4F treated HO-2^(−/−) mouse liver. Values are means ± SE, 𝑛=6,^∗𝑃<0.05 versus WT, and ^#𝑃<0.05 versus HO-2^(−/−). (b) Western blot, densitometry analysis and (c) mRNA expression of hepatic tissues for HO-1 expression. Values are means ± SE, 𝑛=6,^∗𝑃<0.05 versus WT, ^#𝑃<0.05 versus HO-2^(−/−) (d). Effects, L-4F on HO-1 activity measured as described in materials and methods. Results are means ± SE, 𝑛=6,^∗𝑃<0.05 versus HO-2^(−/−).

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