Apo A1 Mimetic Rescues the Diabetic Phenotype of HO-2 Knockout Mice via an Increase in HO-1 Adiponectin and LKBI Signaling Pathway
Effect of L-4F on adiponectin pAMPK and LKB1 expression in HO-2 null. L-4F was administered daily for 6 weeks and liver tissues analyzed for adiponectin protein (a) and mRNA (b) expression. Protein bands were analyzed by densitometry and plotted against a relative expression to actin. Results are means ± SE, , * versus WT, # versus HO-2(−/−). (c) Western blot and densitometry analysis of hepatic tissues for pAMPK and AMPK. Values are means ± SE, versus WT, # versus HO-2(−/−). (d) Expression for LKB1 in WT, HO-2 KO with and without L-4F. Values are means ± SE, versus WT, # versus HO-2(−/−).
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