From Rat to Human: Regulation of Renin-Angiotensin  System Genes by Sry

<table>Human SRY regulation of rat RAS gene promoters. Human SRY (black) increases promoter activity of rat <i>Agt, Ren</i>, and <i>Ace</i> while decreasing <i>Ace2</i> as previously seen with Sry1 and Sry3. Mutations to the proline 131 of hSRY to threonine (gray) significantly increased activity in <i>Ren</i> and <i>Ace2 </i>while they had a trend in decreasing activity on <i>Agt</i> and <i>Ace</i>. Significance of hSRY is based on comparison to the control vector (blue) or for hSRY P131T to the hSRY values. <svg height="17.825001" id="M13" style="vertical-align:-3.276pt" version="1.1" viewbox="0 0 69.150002 17.825001" width="69.150002" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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International Journal of Hypertension

fig3

Figure 3

Figure 3: From Rat to Human: Regulation of Renin-Angiotensin  System Genes by Sry 