From Rat to Human: Regulation of Renin-Angiotensin System Genes by Sry

Figure 4

Human SRY regulation of the human RAS gene promoters. Human SRY (hSRY, black) significantly regulated human AGT, REN, ACE 2, AT2, and MAS promoters. Significance of hSRY is based on comparison to the control vector (blue). The mutation at amino acid 131 (hSRY P131T, gray) significantly diminished function in AGT, REN, ACE 2, AT2, and MAS constructs relative to hSRY. Sry3 (red) significantly regulated AGT, ACE2, AT2, and MAS compared to control (blue). ^∗𝑃≤0.05, ^∗∗𝑃≤0.01, ^∗∗∗𝑃≤0.001.