International Journal of Hypertension / 2012 / Article / Fig 1

Research Article

Reciprocal Effects of Oxidative Stress on Heme Oxygenase Expression and Activity Contributes to Reno-Vascular Abnormalities in EC-SOD Knockout Mice

Figure 1

(a) Detection of EC-SOD mRNA transcripts by RT-PCR analysis in renal tissues. EC-SOD(−/−) animals demonstrated significant ( ) reduction in EC-SOD mRNA as compared to their WT counterparts, and the administration of CoPP had no significant effect on SOD3 mRNA levels in both WT and KO animals. Results are expressed as mean ± SE, * versus WT mice. (b) Western blot analysis of HO-1 and HO-2 proteins in kidney homogenates of WT and EC-SOD(−/−) mice. Immunoblots were performed using antibodies against mice HO-1 and HO-2 proteins. Blots are representative of six separate experiments. Results are expressed as mean ± SE, * versus WT, + versus WT + CoPP, versus EC-SOD(−/−). (c) Bilirubin production in WT, EC-SOD(−/−) mice and EC-SOD(−/−) mice treated with CoPP. Values are expressed as the mean ± SD of 4 experiments, * versus WT mice, versus EC-SOD(−/−).

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