International Journal of Hypertension / 2012 / Article / Fig 5

Research Article

Reciprocal Effects of Oxidative Stress on Heme Oxygenase Expression and Activity Contributes to Reno-Vascular Abnormalities in EC-SOD Knockout Mice

Figure 5

The schematic outlines the salient points discussed in the paper. Chronic oxidative stress upregulates HO-1 expression whose products, CO & BV have antioxidant properties and help restore redox homeostasis. In addition, HO induction stimulates epoxide synthesis and these pathways combined enhance adiponectin release. Antioxidant, antiapoptotic, vasomodulatory, and renoprotective properties of HO-EET-adiponectin axis restore cardiovascular-renal homeostasis often disrupted in conditions of oxidative stress. HO induction overcomes a concurrent inhibition of HO activity by redox-dependent mechanisms which offset the protective effects of enhanced HO expression thus contributing towards pathophysiological abnormalities observed in conditions of chronic oxidative stress.

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