Deficiency of ACE2 in Bone-Marrow-Derived Cells Increases Expression of TNF-α in Adipose Stromal Cells and Augments Glucose Intolerance in Obese C57BL/6 Mice
Figure 2
Bone marrow deficiency of ACE2 increases F4/80 and TNF-α mRNA abundance in the stromal vascular fraction (SVF) isolated from visceral adipose tissue of HF-fed C57BL/6 mice. Quantification of mRNA abundance in the SVF isolated from epididymal adipose (EF, a), retroperitoneal adipose (RPF, b), or subcutaneous fat (SubQ, c) of chimeric mice transplanted with Ace2+/y (depicted on the x-axis as +) or −/y (depicted on the x-axis as−) bone marrow. Data are mean SEM from 3–11 mice/donor genotype. *: compared to +.
