Beneficial Effects of Long-Term Administration of an Oral Formulation of Angiotensin-(1–7) in Infarcted Rats

Table 1

Functional parameters during long term of continuous treatment with HPβCD/Ang-(1–7) in infarcted rats.

Sham

MI

MI + HPβCD/Ang-(1–7)

Parameters

Before

Days after surgery

Before

Days after surgery

Before

Days after surgery

surgery

15

30

50

surgery

15

30

50

surgery

15

30

50

Body weight (g)

188±6

264±6

342±12

404±11

191±12

243±11

307±12

351±14

213±14

272±10

334±9

380±11

LV mass (mg)

531±39

695±29

740±34

793±44

503±31

740±44

715±26

901±62

479±54

640±43

747±46

780±60

SV (μL)

147±9.6

179±10

173±7.8

181±7.8

148±10

147±10.3

141±13.8

163±9.5

133±12

170±8.5

166±8.9

175±11

HR (bpm)

399±17

395±11

403±16

380±12

377±10

367±23

359±10

351±11

410±6

366±10

378±11

368±11

CO (mL/min)

58±4

70±4

70±4

69±4

56±4

55±7

51±6

57±3

54±4

61±3

63±4

65±5

Data are expressed as mean ± SEM. No significant differences were observed among any of the groups (two-way ANOVA followed by Bonferroni posttest). MI: myocardial infarction; LV: left ventricle; SV: stroke volume; HR: heart rate; CO: cardiac output.