Review Article

Heme Oxygenase-1 Induction and Organic Nitrate Therapy: Beneficial Effects on Endothelial Dysfunction, Nitrate Tolerance, and Vascular Oxidative Stress

Figure 7

Comparison of the 3′-UTR of the HO-1 mRNA of different species. (a) The 3′-UTR sequences of the HO-1 mRNA from rat, mouse, rhesus macaque, chimpanzee and human was compared using the ECR-Browser software. The search area was 10 bp and the minimal homology was 80%. The height of the curves (50% < < 100%) indicates the homology (red = intergenic regions, yellow = untranslated regions of the RNA (UTR), blue = exon, pink ECR, above). (b) Using the software RNALogo (http://rnalogo.mbc.nctu.edu.tw/createlogo.html) a consensus sequence of all 5 3′-UTR sequences was generated. The height of the letters indicate the frequency of the appearance of this base. AREs are marked by a red box. A putative HuR binding site is indicated.
842632.fig.007a
(a)
842632.fig.007b
(b)