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International Journal of Hypertension
Volume 2012 (2012), Article ID 958298, 8 pages
http://dx.doi.org/10.1155/2012/958298
Research Article

AVE0991, a Nonpeptide Compound, Attenuates Angiotensin II-Induced Vascular Smooth Muscle Cell Proliferation via Induction of Heme Oxygenase-1 and Downregulation of p-38 MAPK Phosphorylation

1Acute and Intensive Care Department, Guangdong General Hospital, Guangdong Academy of Medical Science, Guangzhou 510080, China
2Department of Gynaecology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China
3Department of Cardiology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China

Received 28 July 2011; Revised 24 October 2011; Accepted 11 November 2011

Academic Editor: Anderson J. Ferreira

Copyright © 2012 Chen Sheng-Long et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [14 citations]

The following is the list of published articles that have cited the current article.

  • Ying-Dong Zhang, Teng Jiang, Li Gao, and Jie Lu, “ACE2-Ang-(1-7)-Mas Axis in Brain: A Potential Target for Prevention and Treatment of Ischemic Stroke,” Current Neuropharmacology, vol. 11, no. 2, pp. 209–217, 2013. View at Publisher · View at Google Scholar
  • Carolyn Clarke, Monica Flores-Muñoz, Clare A. McKinney, Graeme Milligan, and Stuart A. Nicklin, “Regulation of cardiovascular remodeling by the counter-regulatory axis of the renin-angiotensin system,” Future Cardiology, vol. 9, no. 1, pp. 23–38, 2013. View at Publisher · View at Google Scholar
  • Yonghong Li, Qixin Wang, Qingke Xu, Shanglang Cai, Jingwei Zhou, Beibei Ren, Tingru Sun, Xu Liu, and Haichu Yu, “Valsartan decreases neointimal hyperplasia in balloon-injured rat aortic arteries by upregulating HO-1 and inhibiting angiotensin II type 1 receptor,” Life Sciences, 2014. View at Publisher · View at Google Scholar
  • Robson Augusto Santos, “Angiotensin-(1-7),” Hypertension, vol. 63, no. 6, pp. 1138–1147, 2014. View at Publisher · View at Google Scholar
  • Clare A. McKinney, Caroline Fattah, Christopher M. Loughrey, Graeme Milligan, and Stuart A. Nicklin, “Angiotensin-(1–7) and angiotensin-(1–9): function in cardiac and vascular remodelling,” Clinical Science, vol. 126, no. 12, pp. 815–827, 2014. View at Publisher · View at Google Scholar
  • Maciej Suski, Anna Gębska, Rafal Olszanecki, Aneta Stachowicz, Danuta Uracz, Jozef Madej, and Ryszard Korbut, “Influence of atorvastatin on angiotensin i metabolism in resting and TNF-α -activated rat vascular smooth muscle cells,” JRAAS - Journal of the Renin-Angiotensin-Aldosterone System, vol. 15, no. 4, pp. 378–383, 2014. View at Publisher · View at Google Scholar
  • Michael Bader, Natalia Alenina, Miguel A. Andrade-Navarro, and Robson A. Santos, “Mas and Its Related G Protein-Coupled Receptors, Mrgprs,” Pharmacological Reviews, vol. 66, no. 4, pp. 1080–1105, 2014. View at Publisher · View at Google Scholar
  • Robson Augusto Santos, “Angiotensin-(1-7),” Hypertension, vol. 63, no. 6, pp. 1138–1147, 2014. View at Publisher · View at Google Scholar
  • Sabine Klein, Chandana B. Herath, Robert Schierwagen, Josephine Grace, Tom Haltenhof, Frank E. Uschner, Christian P. Strassburg, Tilman Sauerbruch, Thomas Walther, Peter W. Angus, and Jonel Trebicka, “Hemodynamic Effects of the Non-Peptidic Angiotensin-(1-7) Agonist AVE0991 in Liver Cirrhosis,” Plos One, vol. 10, no. 9, 2015. View at Publisher · View at Google Scholar
  • Maria Gabriela Morales, Hugo Olguin, Gabriella Di Capua, Enrique Brandan, Felipe Simon, and Claudio Cabello-Verrugio, “Endotoxin-induced skeletal muscle wasting is prevented by angiotensin-(1-7) through a p38 MAPK-dependent mechanism,” Clinical Science, vol. 129, no. 6, pp. 461–476, 2015. View at Publisher · View at Google Scholar
  • Xiao-Mei Bao, and Hongchao Zheng, “Atorvastatin attenuates homocysteine-induced migration of smooth muscle cells through mevalonate pathway involving reactive oxygen species and p38 MAPK,” Clinical and Experimental Pharmacology and Physiology, vol. 42, no. 8, pp. 865–873, 2015. View at Publisher · View at Google Scholar
  • Feng Zhang, Xingsheng Ren, Mingxia Zhao, Bing Zhou, and Ying Han, “Angiotensin-(1–7) abrogates angiotensin II-induced proliferation, migration and inflammation in VSMCs through inactivation of ROS-mediated PI3K/Akt and MAPK/ERK signaling pathways,” Scientific Reports, vol. 6, pp. 34621, 2016. View at Publisher · View at Google Scholar
  • Abolfazl Zarjou, Anupam Agarwa, Anita Ayer, and Roland Stocker, “Heme oxygenases in cardiovascular health and disease,” Physiological Reviews, vol. 96, no. 4, pp. 1449–1508, 2016. View at Publisher · View at Google Scholar
  • Shuangquan Yan, Yiran Wang, Panpan Liu, Ali Chen, Mayun Chen, Dan Yao, Xiaomei Xu, Liangxing Wang, and Xiaoying Huang, “Baicalin Attenuates Hypoxia-Induced Pulmonary Arterial Hypertension to Improve Hypoxic Cor Pulmonale by Reducing the Activity of the p38 MAPK Signaling Pathway and MMP-9,” Evidence-Based Complementary and Alternative Medicine, vol. 2016, pp. 1–9, 2016. View at Publisher · View at Google Scholar