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International Journal of Hypertension
Volume 2013, Article ID 329602, 9 pages
http://dx.doi.org/10.1155/2013/329602
Clinical Study

Cerebral White Matter and Retinal Arterial Health in Hypertension and Type 2 Diabetes Mellitus

1Brain, Obesity, and Diabetes Laboratory (BODyLab), Department of Psychiatry, New York University School of Medicine, 145 East 32nd Street, 8th Floor, New York, NY 10016, USA
2Department of Medicine, New York University School of Medicine, 145 East 32nd Street, 8th Floor, New York, NY 10016, USA
3Nathan Kline Institute for Psychiatric Research, 140 Old Orangeburg Road Orangeburg, NY 10962, USA

Received 6 March 2013; Revised 28 June 2013; Accepted 30 June 2013

Academic Editor: Kazuomi Kario

Copyright © 2013 P. L. Yau et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. Center for Disease Control, “National diabetes fact sheet: national estimates and general information on diabetes and prediabetes in the United States, 2011,” Centers for Disease Control and Prevention, 2011.
  2. Center for Disease Control, “Vital signs: prevalence, treatment, and control of hypertension—United States, 1999–2002 and 2005–2008,” Morbidity and Mortality Weekly Report, vol. 60, no. 4, pp. 103–108, 2011. View at Google Scholar
  3. S. E. Vermeer, M. Hollander, E. J. Van Dijk, A. Hofman, P. J. Koudstaal, and M. M. B. Breteler, “Silent brain infarcts and white matter lesions increase stroke risk in the general population: The Rotterdam Scan Study,” Stroke, vol. 34, no. 5, pp. 1126–1129, 2003. View at Publisher · View at Google Scholar · View at Scopus
  4. S. M. Gold, I. Dziobek, K. Rogers, A. Bayoumy, P. F. McHugh, and A. Convit, “Hypertension and hypothalamo-pituitary-adrenal axis hyperactivity affect frontal lobe integrity,” Journal of Clinical Endocrinology and Metabolism, vol. 90, no. 6, pp. 3262–3267, 2005. View at Publisher · View at Google Scholar · View at Scopus
  5. D. H. Salat, D. N. Greve, J. L. Pacheco et al., “Regional white matter volume differences in nondemented aging and Alzheimer's disease,” NeuroImage, vol. 44, no. 4, pp. 1247–1258, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. S. M. Gold, I. Dziobek, V. Sweat et al., “Hippocampal damage and memory impairments as possible early brain complications of type 2 diabetes,” Diabetologia, vol. 50, no. 4, pp. 711–719, 2007. View at Publisher · View at Google Scholar · View at Scopus
  7. T. Den Heijer, S. E. Vermeer, E. J. Van Dijk et al., “Type 2 diabetes and atrophy of medial temporal lobe structures on brain MRI,” Diabetologia, vol. 46, no. 12, pp. 1604–1610, 2003. View at Publisher · View at Google Scholar · View at Scopus
  8. S. Burgmans, M. P. J. van Boxtel, E. H. B. M. Gronenschild et al., “Multiple indicators of age-related differences in cerebral white matter and the modifying effects of hypertension,” NeuroImage, vol. 49, no. 3, pp. 2083–2093, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. P. L. Yau, D. Javier, W. Tsui et al., “Emotional and neutral declarative memory impairments and associated white matter microstructural abnormalities in adults with type 2 diabetes,” Psychiatry Research, vol. 174, no. 3, pp. 223–230, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. C. Yang, A. DeVisser, J. A. Martinez et al., “Differential impact of diabetes and hypertension in the brain: adverse effects in white matter,” Neurobiology of Disease, vol. 42, no. 3, pp. 446–458, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. M. H. Schutta, “Diabetes and hypertension: epidemiology of the relationship and pathophysiology of factors associated with these comorbid conditions,” Journal of the Cardiometabolic Syndrome, vol. 2, no. 2, pp. 124–130, 2007. View at Publisher · View at Google Scholar · View at Scopus
  12. S. Hughes, H. Yang, and T. Chan-Ling, “Vascularization of the human fetal retina: roles of vasculogenesis and angiogenesis,” Investigative Ophthalmology and Visual Science, vol. 41, no. 5, pp. 1217–1228, 2000. View at Google Scholar · View at Scopus
  13. N. Patton, T. Aslam, T. MacGillivray, A. Pattie, I. J. Deary, and B. Dhillon, “Retinal vascular image analysis as a potential screening tool for cerebrovascular disease: a rationale based on homology between cerebral and retinal microvasculatures,” Journal of Anatomy, vol. 206, no. 4, pp. 319–348, 2005. View at Publisher · View at Google Scholar · View at Scopus
  14. M. K. Ikram, J. C. M. Witteman, J. R. Vingerling, M. M. B. Breteler, A. Hofman, and P. T. V. M. De Jong, “Retinal vessel diameters and risk of hypertension: The Rotterdam Study,” Hypertension, vol. 47, no. 2, pp. 189–194, 2006. View at Publisher · View at Google Scholar · View at Scopus
  15. H.-M. Kwon, B. J. Kim, J. Y. Oh et al., “Retinopathy as an indicator of silent brain infarction in asymptomatic hypertensive subjects,” Journal of the Neurological Sciences, vol. 252, no. 2, pp. 159–162, 2007. View at Publisher · View at Google Scholar · View at Scopus
  16. A. Tirsi, H. Bruehl, V. Sweat et al., “Retinal vessel abnormalities are associated with elevated fasting insulin levels and cerebral atrophy in nondiabetic individuals,” Ophthalmology, vol. 116, no. 6, pp. 1175–1181, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. A. Tirsi, M. Duong, W. Tsui et al., “Retinal vessel abnormalities as a possible biomarker of brain volume loss in obese adolescents,” Obesity, 2013. View at Google Scholar
  18. K. Bettermann, J. E. Slocomb, V. Shivkumar et al., “Retinal vasoreactivity as a marker for chronic ischemic white matter disease?” Journal of the Neurological Sciences, vol. 322, no. 1-2, pp. 206–210, 2012. View at Google Scholar
  19. V. C. Hachinski, “Differential diagnosis of Alzheimer's dementia: multi-infarct dementia,” in Alzheimer's Disease, B. Reisberg, Ed., pp. 188–192, Free Press, New York, NY, USA, 1983. View at Google Scholar
  20. P. Scheltens, F. Barkhof, D. Leys et al., “A semiquantitative rating scale for the assessment of signal hyperintensities on magnetic resonance imaging,” Journal of the Neurological Sciences, vol. 114, no. 1, pp. 7–12, 1993. View at Publisher · View at Google Scholar · View at Scopus
  21. M. D. Knudtson, K. E. Lee, L. D. Hubbard, T. Y. Wong, R. Klein, and B. E. K. Klein, “Revised formulas for summarizing retinal vessel diameters,” Current Eye Research, vol. 27, no. 3, pp. 143–149, 2003. View at Publisher · View at Google Scholar · View at Scopus
  22. F. Cazettes, J. I. Cohen, P. L. Yau, H. Talbot, and A. Convit, “Obesity-mediated inflammation may damage the brain circuit that regulates food intake,” Brain Research, vol. 1373, pp. 101–109, 2011. View at Publisher · View at Google Scholar · View at Scopus
  23. E. A. Francischetti and V. A. Genelhu, “Obesity-hypertension: an ongoing pandemic,” International Journal of Clinical Practice, vol. 61, no. 2, pp. 269–280, 2007. View at Publisher · View at Google Scholar · View at Scopus
  24. Y. Benjamini and Y. Hochberg, “Controlling the false discovery rate: a practical and powerful approach to multiple testing,” Journal of the Royal Statistical Society Series B, vol. 57, no. 1, pp. 289–300, 1995. View at Google Scholar
  25. A. M. J. MacLullich, K. J. Ferguson, L. M. Reid et al., “Higher systolic blood pressure is associated with increased water diffusivity in normal-appearing white matter,” Stroke, vol. 40, no. 12, pp. 3869–3871, 2009. View at Publisher · View at Google Scholar · View at Scopus
  26. K. Hannesdottir, A. Nitkunan, R. A. Charlton, T. R. Barrick, G. A. MacGregor, and H. S. Markus, “Cognitive impairment and white matter damage in hypertension: a pilot study,” Acta Psychiatrica et Neurologica Scandinavica, vol. 119, no. 4, pp. 261–268, 2009. View at Publisher · View at Google Scholar · View at Scopus
  27. L. Huang, X.-Y. Ling, and S.-R. Liu, “Diffusion tensor imaging on white matter in normal adults and elderly patients with hypertension,” Chinese Medical Journal, vol. 119, no. 15, pp. 1304–1307, 2006. View at Google Scholar · View at Scopus
  28. R. A. R. Gons, K. F. De Laat, A. G. W. Van Norden et al., “Hypertension and cerebral diffusion tensor imaging in small vessel disease,” Stroke, vol. 41, no. 12, pp. 2801–2806, 2010. View at Publisher · View at Google Scholar · View at Scopus
  29. V. I. H. Kwa, J. J. Van der Sande, J. Stam, N. Tijmes, and J. L. Vrooland, “Retinal arterial changes correlate with cerebral small-vessel disease,” Neurology, vol. 59, no. 10, pp. 1536–1540, 2002. View at Google Scholar · View at Scopus
  30. K. F. Yates, V. Sweat, P. L. Yau et al., “Impact of metabolic syndrome on cognition and brain: a selected review of the literature,” Arteriosclerosis,Thrombosis, and Vascular Biology, vol. 32, no. 9, pp. 2060–2067, 2012. View at Google Scholar
  31. V. L. Starr and A. Convit, “Diabetes, sugar-coated but harmful to the brain,” Current Opinion in Pharmacology, vol. 7, no. 6, pp. 638–642, 2007. View at Publisher · View at Google Scholar · View at Scopus
  32. G. L. Schwartz, K. R. Bailey, T. Mosley et al., “Association of ambulatory blood pressure with ischemic brain injury,” Hypertension, vol. 49, no. 6, pp. 1228–1234, 2007. View at Publisher · View at Google Scholar · View at Scopus
  33. Y. M. Traub, A. P. Shapiro, M. Dujovny, and D. Nelson, “Cerebral blood flow changes with diuretic therapy in elderly subjects with systolic hypertension,” Clinical and Experimental Hypertension Part A, vol. 4, no. 7, pp. 1193–1201, 1982. View at Google Scholar · View at Scopus