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International Journal of Hypertension
Volume 2013, Article ID 351357, 6 pages
http://dx.doi.org/10.1155/2013/351357
Research Article

Metabolic Alterations in Different Stages of Hypertension in an Apparently Healthy Nigerian Population

1Department of Chemical Pathology, College of Medicine, University of Ibadan, Ibadan 200284, Nigeria
2Department of Medicine, College of Medicine, University of Ibadan, Ibadan 200284, Nigeria
3Department of Haematology, College of Medicine, University of Ibadan, Ibadan 200284, Nigeria
4Department of Health Promotion and Education, College of Medicine, University of Ibadan, Ibadan 200284, Nigeria
5Medical Social Services Department, University College Hospital, Ibadan 200212, Nigeria
6Dietetics Department, University College Hospital, Ibadan 200212, Nigeria
7Department of Chemical Pathology, College of Health Sciences, Olabisi Onabanjo University, Ago-Iwoye 120005, Nigeria
8General Out Patient Unit, University College Hospital, Ibadan 200212, Nigeria

Received 29 May 2013; Revised 18 September 2013; Accepted 22 October 2013

Academic Editor: Mandy Kwan

Copyright © 2013 M. A. Charles-Davies et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Metabolic syndrome (MS) amplifies hypertension (HTN) associated with increased risk of cardiovascular disease (CVD). MS components and other CVD risk measures were investigated in different stages of hypertension. 534 apparently healthy Nigerian traders aged 18–105 years were participants of a cohort study. The International Diabetes Federation (2005) and the National High Blood Pressure Education Program Coordinating Committee criteria were used for MS and HTN classifications, respectively. Anthropometric indices were obtained by standard methods. Levels of fasting plasma glucose (FPG), total cholesterol (TC), triglyceride (TG), and high-density lipoprotein cholesterol (HDLC) were determined by enzymatic methods, while low-density lipoprotein cholesterol (LDLC) was calculated. Data analysed statistically were significant at . 143 (26.8%), 197 (36.9%), and 194 (36.3%) of the traders had normotension, pre-HTN and HTN (stages 1 and 2), respectively. All indices tested except HDLC were significantly different among BP groups ( ). Waist to hip (WHR) and waist to height (WHT) ratios were significantly different between HTN groups ( ). HTN was associated with MS and female gender ( ). Metabolic alterations and significant HTN were observed. Treatment of the individual components of the syndrome and improvement of modifiable metabolic factors may be necessary to reduce MS and high BP.