International Journal of Hypertension / 2013 / Article / Tab 4

Clinical Study

Genetic and Adverse Health Outcome Associations with Treatment Resistant Hypertension in GenHAT

Table 4

Significant gene associations with treatment resistant hypertension.

Variant name Rs number Geno-typeAfrican AmericanWhite
TRH casesControlsOdds ratio (95% CI)* value*TRH casesControlsOdds ratio (95% CI)* value*

TT640 (70.6)463 (66.5)228 (18.2)380 (23.5)
AGTM235T699TM237 (26.1)203 (29.2)0.83 (0.67–1.03)0.10597 (47.5)801 (49.6)1.27 (1.12–1.44)0.0001
MM30 (3.3)30 (4.3)431 (34.3)434 (26.9)

AA658 (72.0)496 (69.9)226 (18.1)401 (24.7)
AGT-6G5051AG231 (25.3)187 (26.3)0.90 (0.72–1.12)0.35597 (47.9)806 (49.7)1.36 (1.20–1.53)<0.0001
GG25 (2.7)27 (3.8)424 (34.0)414 (25.5)

Odds of being a case versus control for each copy of the minor allele (additive genetic model) after adjustment for age, sex, randomized treatment group, baseline values of BMI, HDL, eGFR, SBP, and DBP, smoking status, diabetes status, and history of LVH.

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