Genetic and Adverse Health Outcome Associations with Treatment Resistant Hypertension in GenHAT
Table 4
Significant gene associations with treatment resistant hypertension.
Variant name
Rs number
Geno-type
African American
White
TRH cases
Controls
Odds ratio (95% CI)*
value*
TRH cases
Controls
Odds ratio (95% CI)*
value*
TT
640 (70.6)
463 (66.5)
228 (18.2)
380 (23.5)
AGTM235T
699
TM
237 (26.1)
203 (29.2)
0.83 (0.67–1.03)
0.10
597 (47.5)
801 (49.6)
1.27 (1.12–1.44)
0.0001
MM
30 (3.3)
30 (4.3)
431 (34.3)
434 (26.9)
AA
658 (72.0)
496 (69.9)
226 (18.1)
401 (24.7)
AGT-6G
5051
AG
231 (25.3)
187 (26.3)
0.90 (0.72–1.12)
0.35
597 (47.9)
806 (49.7)
1.36 (1.20–1.53)
<0.0001
GG
25 (2.7)
27 (3.8)
424 (34.0)
414 (25.5)
Odds of being a case versus control for each copy of the minor allele (additive genetic model) after adjustment for age, sex, randomized treatment group, baseline values of BMI, HDL, eGFR, SBP, and DBP, smoking status, diabetes status, and history of LVH.
