Genetic and Adverse Health Outcome Associations with Treatment Resistant Hypertension in GenHAT
Table 5
Gene associations with treatment resistant hypertension that are suggestive for both AA and white participants.
Variant name
Rs number
Geno-type
African American
White
TRH cases
Controls
Odds ratio (95% CI)*
value*
TRH cases
Controls
Odds ratio (95% CI)*
value*
CC
717 (78.8)
508 (72.7)
564 (44.8)
662 (40.9)
MTHFR
1801133
CT
178 (19.6)
175 (25.0)
0.67 (0.52–0.86)
0.002
555 (44.1)
751 (46.4)
0.88 (0.77–0.99)
0.04
TT
15 (1.7)
16 (2.3)
139 (11.1)
207 (12.8)
AA
750 (82.3)
553 (79.1)
345 (27.6)
502 (31.2)
MMP3 5A/6A
3025058
*A
153 (16.8)
133 (19.0)
0.75 (0.57–0.98)
0.04
601 (48.1)
778 (48.4)
1.14 (1.01–1.29)
0.03
**
8 (0.9)
13 (1.9)
304 (24.3)
327 (20.4)
GG
842 (92.7)
666 (95.0)
1115 (88.7)
1470 (91.0)
TNF
361525
GA
63 (6.9)
34 (4.9)
1.87 (1.13–3.11)
0.02
139 (11.1)
143 (8.9)
1.44 (1.10–1.90)
0.009
AA
3 (0.3)
1 (0.1)
3 (0.2)
2 (0.1)
Odds of being a case versus control for each copy of the minor allele (additive genetic model) after adjustment for age, sex, randomized treatment group, baseline values of BMI, HDL, eGFR, SBP, and DBP, smoking status, diabetes status, and history of LVH.
