Table of Contents Author Guidelines Submit a Manuscript
International Journal of Hypertension
Volume 2013, Article ID 653789, 15 pages
http://dx.doi.org/10.1155/2013/653789
Review Article

Impact of Diabetes on Cardiovascular Disease: An Update

1Department of Internal Medicine, Diabetes Unit, State University of Rio de Janeiro, Avenida 28 de Setembro 77, Terceiro Andar, Vila Isabel, 20551-030 Rio de Janeiro, RJ, Brazil
2Department of Internal Medicine, Bauru's Diabetics Association, Rua Saint Martin 27-07, 17.012-433 Bauru, SP, Brazil

Received 6 December 2012; Revised 31 January 2013; Accepted 31 January 2013

Academic Editor: Mario Fritsch Neves

Copyright © 2013 Alessandra Saldanha de Mattos Matheus et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [96 citations]

The following is the list of published articles that have cited the current article.

  • Matthew Butcher, and Elena V. Galkina, “Old suspect - New evidence: The role of PKCβ in diabetes mellitus-accelerated atherosclerosis,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 33, no. 8, pp. 1737–1738, 2013. View at Publisher · View at Google Scholar
  • Edoardo Mannucci, and Ilaria Dicembrini, “Overview on cardiovascular risk factors in diabetes: Focus on hypoglycemia, dyslipidemia, weight and cardiovascular disease,” Giornale Italiano di Cardiologia, vol. 14, no. 12, 2013. View at Publisher · View at Google Scholar
  • Changfu Lin, Haijing Sui, Jie Gu, Xue Yang, Lin Deng, Wenzhi Li, Wengang Ding, Dongmei Li, and Yingchun Yang, “Effect and mechanism of propofol on myocardial ischemia reperfusion injury in type 2 diabetic rats,” Microvascular Research, vol. 90, pp. 162–168, 2013. View at Publisher · View at Google Scholar
  • Roland E. Schmieder, Rudolph Schutte, Helmut Schumacher, Michael Böhm, Giuseppe Mancia, Michael A. Weber, Matthew McQueen, Koon Teo, and Salim Yusuf, “Mortality and morbidity in relation to changes in albuminuria, glucose status and systolic blood pressure: an analysis of the ONTARGET and TRANSCEND studies,” Diabetologia, vol. 57, no. 10, pp. 2019–2029, 2014. View at Publisher · View at Google Scholar
  • Marcelo Mendonca Mota, Tharciano Luiz Teixeira Braga da Silva, Milene Tavares Fontes, Andre Sales Barreto, Joao Eliakim dos Santos Araujo, Antonio Cesar Cabral de Oliveira, Rogerio Brandao Wichi, and Marcio Roberto Viana Santos, “Resistance Exercise Restores Endothelial Function and Reduces Blood Pressure in Type 1 Diabetic Rats,” Arquivos Brasileiros de Cardiologia, vol. 103, no. 1, pp. 25–32, 2014. View at Publisher · View at Google Scholar
  • Andrew G. Kirkley, and Robert M. Sargis, “Environmental Endocrine Disruption of Energy Metabolism and Cardiovascular Risk,” Current Diabetes Reports, vol. 14, no. 6, 2014. View at Publisher · View at Google Scholar
  • C. Oggioni, J. Lara, J.C.K. Wells, K. Soroka, and M. Siervo, “Shifts in population dietary patterns and physical inactivity as determinants of global trends in the prevalence of diabetes: An ecological analysis,” Nutrition, Metabolism and Cardiovascular Diseases, 2014. View at Publisher · View at Google Scholar
  • Rong Guo, Baoxin Liu, Ke Wang, Shunping Zhou, Weiming Li, and Yawei Xu, “Resveratrol ameliorates diabetic vascular inflammation and macrophage infiltration in db/db mice by inhibiting the NF-kappa B pathway,” Diabetes & Vascular Disease Research, vol. 11, no. 2, pp. 92–102, 2014. View at Publisher · View at Google Scholar
  • Omotayo Erejuwa, Siti Sulaiman, and Mohd Wahab, “Modulation of Gut Microbiota in the Management of Metabolic Disorders: The Prospects and Challenges,” International Journal of Molecular Sciences, vol. 15, no. 3, pp. 4158–4188, 2014. View at Publisher · View at Google Scholar
  • Li-Mei Zhao, Yan Wang, Yong Yang, Rong Guo, Nan-Ping Wang, and Xiu-Ling Deng, “Metformin Restores Intermediate-Conductance CalciumActivated K+ channel-and Small-Conductance CalciumActivated K+ channel-Mediated Vasodilatation Impaired by Advanced Glycation End Products in Rat Mesenteric Artery,” Molecular Pharmacology, vol. 86, no. 5, pp. 580–591, 2014. View at Publisher · View at Google Scholar
  • Prudence Tettey, Steve Simpson, Bruce V. Taylor, and Ingrid van der Mei, “The co-occurrence of multiple sclerosis and type 1 diabetes: Shared aetiologic features and clinical implication for MS aetiology,” Journal of the Neurological Sciences, 2014. View at Publisher · View at Google Scholar
  • William J. Elliottpp. 119–134, 2014. View at Publisher · View at Google Scholar
  • M. Macharia, A. P. Kengne, D. M. Blackhurst, R. T. Erasmus, M. Hoffmann, and T. E. Matsha, “Indices of Paraoxonase and Oxidative Status Do Not Enhance the Prediction of Subclinical Cardiovascular Disease in Mixed-Ancestry South Africans,” Oxidative Medicine and Cellular Longevity, vol. 2014, pp. 1–10, 2014. View at Publisher · View at Google Scholar
  • Irma Isordia-Salas, María Eugenia Galván-Plata, Alfredo Leaños-Miranda, Eberth Aguilar-Sosa, Francisco Anaya-Gómez, Abraham Majluf-Cruz, and David Santiago-Germán, “Proinflammatory and Prothrombotic State in Subjects with Different Glucose Tolerance Status before Cardiovascular Disease,” Journal of Diabetes Research, vol. 2014, pp. 1–9, 2014. View at Publisher · View at Google Scholar
  • Mizuho Kinouchi, Itsuro Endo, Munehide Matsuhisa, Toshio Matsumoto, Ken-Ichi Aihara, Yuichi Fujinaka, Sumiko Yoshida, Yukari Ooguro, Kiyoe Kurahashi, Takeshi Kondo, Nanako Aki, and Akio Kuroda, “Diabetic conditions differentially affect the endothelial function, arterial stiffness and carotid atherosclerosis,” Journal of Atherosclerosis and Thrombosis, vol. 21, no. 5, pp. 486–500, 2014. View at Publisher · View at Google Scholar
  • Isabele B. S. Gomes, Marcella L. Porto, Maria C. L. F. S. Santos, Bianca P. Campagnaro, Agata L. Gava, Silvana S. Meyrelles, Thiago M. C. Pereira, and Elisardo C. Vasquez, “The protective effects of oral low-dose quercetin on diabetic nephropathy in hypercholesterolemic mice,” Frontiers in Physiology, vol. 6, 2015. View at Publisher · View at Google Scholar
  • Melita Vidaković, Nevena Grdović, Svetlana Dinić, Mirjana Mihailović, Aleksandra Uskoković, and Jelena ArambaÅ¡ić Jovanović, “The Importance of the CXCL12/CXCR4 Axis in Therapeutic Approaches to Diabetes Mellitus Attenuation,” Frontiers in Immunology, vol. 6, 2015. View at Publisher · View at Google Scholar
  • Aafke W. F. Janssen, and Sander Kersten, “The role of the gut microbiota in metabolic health,” Faseb Journal, vol. 29, no. 8, pp. 3111–3123, 2015. View at Publisher · View at Google Scholar
  • Tue H Hansen, Rikke J Gøbel, Torben Hansen, and Oluf Pedersen, “The gut microbiome in cardio-metabolic health,” Genome Medicine, vol. 7, no. 1, 2015. View at Publisher · View at Google Scholar
  • Tayyebeh Chahkandi, Fatemeh Taheri, Toba Kazemi, and Bita Bijari, “The Prevalence of Diabetes and Prediabetes Among Elementary School Children in Birjand,” Iranian Journal of Pediatrics, vol. 25, no. 1, 2015. View at Publisher · View at Google Scholar
  • Aimee E. Hodson, Trevor S. Tippetts, and Benjamin T. Bikman, “Insulin treatment increases myocardial ceramide accumulation and disrupts cardiometabolic function,” Cardiovascular Diabetology, vol. 14, no. 1, 2015. View at Publisher · View at Google Scholar
  • Rafeek Hidhayath Basha, and Chandrasekaran Sankaranarayanan, “β-Caryophyllene, a natural sesquiterpene lactone attenuates hyperglycemia mediated oxidative and inflammatory stress in experimental diabetic rats,” Chemico-Biological Interactions, 2015. View at Publisher · View at Google Scholar
  • Benjamin M Leon, and Thomas M Maddox, “Diabetes and cardiovascular disease: Epidemiology, biological mechanisms, treatment recommendations and future research.,” World journal of diabetes, vol. 6, no. 13, pp. 1246–58, 2015. View at Publisher · View at Google Scholar
  • I. Saremi, M. Saremi, S. Lotfipanah, S. Imani, T. Y. Zhang, and J. Fu, “Relationship Between Ppargc1a Gene Polymorphisms With The Increased Risk Of Coronary Artery Disease Among Patients With Type 2 Diabetes Mellitus In Ir,” Acta Endocrinologica-Bucharest, vol. 11, no. 1, pp. 13–17, 2015. View at Publisher · View at Google Scholar
  • Wajiha Farooq, Umme Farwa, and Faisal Rashid Khan, “The metabolic syndrome and inflammation role of insulin resistance and increased adiposity,” Oman Medical Journal, vol. 30, no. 2, pp. 100–103, 2015. View at Publisher · View at Google Scholar
  • Bi Huang, Yanmin Yang, Jun Zhu, Yan Liang, Han Zhang, Li Tian, Xinghui Shao, and Juan Wang, “Clinical Characteristics and Impact of Diabetes Mellitus on Outcomes in Patients with Nonvalvular Atrial Fibrillation,” Yonsei Medical Journal, vol. 56, no. 1, pp. 62, 2015. View at Publisher · View at Google Scholar
  • Kalaiselvi, and Nasira, “Prediction of heart diseases and cancer in diabetic patients using data mining techniques,” Indian Journal of Science and Technology, vol. 8, no. 14, 2015. View at Publisher · View at Google Scholar
  • C. M. Rosa, R. Gimenes, D. H. S. Campos, G. N. Guirado, C. Gimenes, A. A. H. Fernandes, A. C. Cicogna, R. M. Queiroz, I. Falcão-Pires, D. Miranda-Silva, P. Rodrigues, F. R. Laurindo, D. C. Fernandes, C. R. Correa, M. P. Okoshi, and K. Okoshi, “Apocynin influence on oxidative stress and cardiac remodeling of spontaneously hypertensive rats with diabetes mellitus,” Cardiovascular Diabetology, vol. 15, no. 1, 2016. View at Publisher · View at Google Scholar
  • Nikitas P. Skliros, Charalambos Vlachopoulos, and Dimitrios Tousoulis, “Treatment of diabetes: Crossing to the other side,” Hellenic Journal of Cardiology, vol. 57, no. 5, pp. 304–310, 2016. View at Publisher · View at Google Scholar
  • Steven P. Marso, Stephen C. Bain, Agostino Consoli, Freddy G. Eliaschewitz, Esteban Jódar, Lawrence A. Leiter, Ildiko Lingvay, Julio Rosenstock, Jochen Seufert, Mark L. Warren, Vincent Woo, Oluf Hansen, Anders G. Holst, Jonas Pettersson, and Tina Vilsbøll, “Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes,” New England Journal of Medicine, 2016. View at Publisher · View at Google Scholar
  • Jay H. Lubin, David Couper, Pamela L. Lutsey, and Hiroshi Yatsuya, “Synergistic and Non-synergistic Associations for Cigarette Smoking and Non-tobacco Risk Factors for Cardiovascular Disease Incidence in the Atherosclerosis Risk In Communities (ARIC) Study,” Nicotine & Tobacco Research, pp. ntw235, 2016. View at Publisher · View at Google Scholar
  • Vasiliki Tsigkou, Spyridon Papaioannou, Gerasimos Siasos, Dimitris Tousoulis, Evangelos Oikonomou, and Georgios Angelos Papamikroulis, “The interaction between gender and diabetes mellitus in the coronary heart disease risk,” Current Pharmaceutical Design, vol. 22, no. 25, pp. 3802–3816, 2016. View at Publisher · View at Google Scholar
  • Margarita Saiz Satjes, and Francisco J Martinez-Martin, “Treatment of hypertensive patients with diabetes: beyond blood pressure control and focus on manidipine,” Future Cardiology, 2016. View at Publisher · View at Google Scholar
  • William T. Cefalu, Julio Rosenstock, Derek LeRoith, Lawrence Blonde, and Matthew C. Riddle, “Getting to the "Heart" of the Matter on Diabetic Cardiovascular Disease: "Thanks for the Memory",” Diabetes Care, vol. 39, no. 5, pp. 664–667, 2016. View at Publisher · View at Google Scholar
  • Hemant Kulkarni, Manju Mamtani, Juan Peralta, Marcio Almeida, Thomas D. Dyer, Harald H. Goring, Matthew P. Johnson, Ravindranath Duggirala, Michael C. Mahaney, Rene L. Olvera, Laura Almasy, David C. Glahn, Sarah Williams-Blangero, Joanne E. Curran, and John Blangero, “Soluble Forms of Intercellular and Vascular Cell Adhesion Molecules Independently Predict Progression to Type 2 Diabetes in Mexican American Families,” Plos One, vol. 11, no. 3, 2016. View at Publisher · View at Google Scholar
  • Stavroula Bitsi, Houda Ali, Lauren Maskell, Samir Ounzain, Vidya Mohamed-Ali, and Vishwanie S. Budhram-Mahadeo, “Profound hyperglycemia in knockout mutant mice identifies novel function for POU4F2/Brn-3b in regulating metabolic processes,” American Journal Of Physiology-Endocrinology And Metabolism, vol. 310, no. 5, pp. E303–E312, 2016. View at Publisher · View at Google Scholar
  • Ying Wang, Xiuru Qi, Chunliang Wang, Danning Zhao, Hongjie Wang, and Jianxin Zhang, “Effects of propofol on myocardial ischemia-reperfusion injury in rats with type-2 diabetes mellitus,” Biomedical Reports, vol. 6, no. 1, pp. 69–74, 2016. View at Publisher · View at Google Scholar
  • Leila Saremi, Marzieh Saremi, Shirin Lotfipanah, Saber Imani, Junjiang Fu, and Tianyu Zhang, “Correlation between HFE gene polymorphisms and increased risk of coronary artery disease among patients with type 2 diabetes in Iran,” Turkish Journal Of Medical Sciences, vol. 46, no. 3, pp. 590–596, 2016. View at Publisher · View at Google Scholar
  • Maria Knapik-Kordecka, Anna Rorbach-Dolata, Agnieszka Piwowar, and Ewa Zurawska-Plaksej, “Increased chitotriosidase activity in plasma of patients with type 2 diabetes,” Archives of Medical Science, vol. 12, no. 5, pp. 977–984, 2016. View at Publisher · View at Google Scholar
  • Debabrata Mukherjee, Thomas F. Whayne, and Sarmad Said, “Interrelationships with metabolic syndrome, obesity and cardiovascular risk,” Current Vascular Pharmacology, vol. 14, no. 5, pp. 415–425, 2016. View at Publisher · View at Google Scholar
  • Joshua Juwono, and Ryan D. Martinus, “Does Hsp60 Provide a Link between Mitochondrial Stress and Inflammation in Diabetes Mellitus?,” Journal of Diabetes Research, vol. 2016, pp. 1–6, 2016. View at Publisher · View at Google Scholar
  • Hitomi Miyake, Ippei Kanazawa, and Toshitsugu Sugimoto, “Decreased serum insulin-like growth factor-I level is associated with the increased mortality in type 2 diabetes mellitus,” Endocrine Journal, vol. 63, no. 9, pp. 811–818, 2016. View at Publisher · View at Google Scholar
  • Abdulmonim A. Alqasim, Essam Eldin M. Noureldin, Sami H. Hammadi, and Ghada E. Esheba, “Effect of melatonin versus vitamin D as antioxidant and Hepatoprotective agents in STZ-induced diabetic rats,” Journal of Diabetes & Metabolic Disorders, vol. 16, no. 1, 2017. View at Publisher · View at Google Scholar
  • Tessa J. Barrett, Andrew J. Murphy, Ira J. Goldberg, and Edward A. Fisher, “Diabetes-mediated myelopoiesis and the relationship to cardiovascular risk,” Annals of the New York Academy of Sciences, vol. 1402, no. 1, pp. 31–42, 2017. View at Publisher · View at Google Scholar
  • Sara Lee, “Update on SGLT2 Inhibitors—New Data Released at the American Diabetes Association,” Critical Pathways in Cardiology, vol. 16, no. 3, pp. 93–95, 2017. View at Publisher · View at Google Scholar
  • Courtney A Polenick, Amanda N Leggett, Noah J Webster, Benjamin H Han, Steven H Zarit, and John D Piette, “Multiple Chronic Conditions in Spousal Caregivers of Older Adults With Functional Disability: Associations With Caregiving Difficulties and Gains,” The Journals of Gerontology: Series B, 2017. View at Publisher · View at Google Scholar
  • Mengting Sheng, Zirui Huang, Liming Pan, Min Yu, Cai Yi, Lin Teng, Ling He, Chen Gu, Chunli Xu, and Junming Li, “SOCS2 exacerbates myocardial injury induced by ischemia/reperfusion in diabetic mice and H9c2 cells through inhibiting the JAK-STAT-IGF-1 pathway,” Life Sciences, 2017. View at Publisher · View at Google Scholar
  • Diego C. Musial, Guilherme H. Bomfim, Juan A. Arranz-Tagarro, Iago Méndez-López, Regiane Miranda-Ferreira, Aron Jurkiewicz, Neide H. Jurkiewicz, Antonio G. García, and Juan F. Padín, “Altered mitochondrial function, calcium signaling, and catecholamine release in chromaffin cells of diabetic and SHR rats,” European Journal of Pharmacology, 2017. View at Publisher · View at Google Scholar
  • Hitomi Miyake, Ippei Kanazawa, and Toshitsugu Sugimoto, “Association of Bone Mineral Density, Bone Turnover Markers, and Vertebral Fractures with All-Cause Mortality in Type 2 Diabetes Mellitus,” Calcified Tissue International, 2017. View at Publisher · View at Google Scholar
  • Martin O. Weickert, Ioannis Kyrou, Seley Gharanei, Harpal S. Randeva, and Bee K. Tan, “Fibroblast growth factors: New insights, new targets in the management of diabetes,” Minerva Endocrinologica, vol. 42, no. 3, pp. 248–270, 2017. View at Publisher · View at Google Scholar
  • Petra C. Vinke, Sahar El Aidy, and Gertjan van Dijk, “The Role of Supplemental Complex Dietary Carbohydrates and Gut Microbiota in Promoting Cardiometabolic and Immunological Health in Obesity: Lessons from Healthy Non-Obese Individuals,” Frontiers in Nutrition, vol. 4, 2017. View at Publisher · View at Google Scholar
  • Tone G. Valderhaug, Archana Sharma, Gunnhild Kravdal, Reidun Rønningen, and Ingrid Nermoen, “The usage of fasting glucose and glycated hemoglobin for the identification of unknown type 2 diabetes in high risk patients with morbid obesity,” Scandinavian Journal of Clinical and Laboratory Investigation, pp. 1–8, 2017. View at Publisher · View at Google Scholar
  • B. Tate Cutshall, Jennifer D. Twilla, Andrew S. Olinger, and Carrie S. Oliphant, “A review on cardiovascular effects of newer hypoglycaemic medications,” Annals of Medicine, pp. 1–10, 2017. View at Publisher · View at Google Scholar
  • D. Thompson, N. Morrice, L. Grant, S. Le Sommer, K. Ziegler, P. Whitfield, N. Mody, H.M. Wilson, and M. Delibegovic, “Myeloid protein tyrosine phosphatase 1B (PTP1B) deficiency protects against atherosclerotic plaque formation in the ApoE ?/? mouse model of atherosclerosis with alterations in IL10/AMPK? pathway,” Molecular Metabolism, 2017. View at Publisher · View at Google Scholar
  • Michael E. Røder, “Hyperproinsulinemia in obesity and in type 2 diabetes and its relation to cardiovascular disease,” Expert Review of Endocrinology & Metabolism, pp. 1–13, 2017. View at Publisher · View at Google Scholar
  • Archana Giri, Lori Rastogi, Karunasagar, and Sashidhar, “Peroxidase-like activity of gum kondagogu reduced/stabilized palladium nanoparticles and its analytical application for colorimetric detection of glucose in biological samples,” Sensors and Actuators, B: Chemical, vol. 240, pp. 1182–1188, 2017. View at Publisher · View at Google Scholar
  • Nirmal Sunkara, and Chowdhury H. Ahsan, “Hypertension in diabetes and the risk of cardiovascular disease,” Cardiovascular Endocrinology, vol. 6, no. 1, pp. 33–38, 2017. View at Publisher · View at Google Scholar
  • Konstantinos Imprialos, Charles Faselis, Konstantinos Stavropoulos, Vasilios Athyros, Asterios Karagiannis, Michael Doumas, and Chrysoula Boutari, “SGLT-2 inhibitors and cardiovascular risk in diabetes mellitus: A comprehensive and critical review of the literature,” Current Pharmaceutical Design, vol. 23, no. 10, pp. 1510–1521, 2017. View at Publisher · View at Google Scholar
  • Zeqing Zhang, Xi Chen, Puhan Lu, Jianhua Zhang, Yongping Xu, Wentao He, Mengni Li, Shujun Zhang, Jing Jia, Shiying Shao, Junhui Xie, Yan Yang, and Xuefeng Yu, “Incretin-based agents in type 2 diabetic patients at cardiovascular risk: compare the effect of GLP-1 agonists and DPP-4 inhibitors on cardiovascular and pancreatic outcomes,” Cardiovascular Diabetology, vol. 16, no. 1, 2017. View at Publisher · View at Google Scholar
  • Solaf Ahmed Kamel, Mona Hamed, Eman Awadallah, Nevine Ibrahim Musa, Nehal Salah Hasan, Amany Hosny Abdel Rahman, and Ghada Hussein Sayed Hussein, “Peroxisome proliferator-activated receptor-γ polymorphism (rs1801282) is associated with obesity in Egyptian patients with coronary artery disease and type 2 diabetes mellitus,” Journal of Genetic Engineering and Biotechnology, vol. 15, no. 2, pp. 409–414, 2017. View at Publisher · View at Google Scholar
  • Michael E. Røder, “Major adverse cardiovascular event reduction with GLP-1 and SGLT2 agents: evidence and clinical potential,” Therapeutic Advances in Chronic Disease, pp. 204062231773528, 2017. View at Publisher · View at Google Scholar
  • Kristen M George, Elizabeth Selvin, James S Pankow, B Gwen Windham, and Aaron R Folsom, “Sex Differences in the Association of Diabetes With Cardiovascular Disease Outcomes Among African-American and White Participants in the Atherosclerosis Risk in Communities Study,” American Journal of Epidemiology, vol. 187, no. 3, pp. 403–410, 2017. View at Publisher · View at Google Scholar
  • Emma K. Lees, Nimesh Mody, Dawn Thompson, Nicola Morrice, Louise Grant, Samantha Le Sommer, Heather M. Wilson, and Mirela Delibegovic, “Pharmacological inhibition of protein tyrosine phosphatase 1B protects against atherosclerotic plaque formation in the LDLR-/- mouse model of atherosclerosis,” Clinical Science, vol. 131, no. 20, pp. 2489–2501, 2017. View at Publisher · View at Google Scholar
  • Bain, and Chudleigh, “GLP-1 receptor agonist Treatment of type 2 diabetes,” Drugs of the Future, vol. 42, no. 8, pp. 479–487, 2017. View at Publisher · View at Google Scholar
  • Ivanildo I. da S. Júnior, Humberto de Moura Barbosa, Débora C. R. Carvalho, Ruideglan de Alencar Barros, Flávia Peixoto Albuquerque, Dionísio Henrique Amaral da Silva, Grasielly R. Souza, Nathália A. C. Souza, Larissa A. Rolim, Flaviane M. M. Silva, Glória I. B. P. Duarte, Jackson R. G. da S. Almeida, Flávio Monteiro de Oliveira Júnior, Dayane A. Gomes, and Eduardo C. Lira, “ Brazilian Morus nigra Attenuated Hyperglycemia, Dyslipidemia, and Prooxidant Status in Alloxan-Induced Diabetic Rats ,” The Scientific World Journal, vol. 2017, pp. 1–10, 2017. View at Publisher · View at Google Scholar
  • Konstantinos Makrilakis, and Stavros Liatis, “Cardiovascular Screening for the Asymptomatic Patient with Diabetes: More Cons Than Pros,” Journal of Diabetes Research, vol. 2017, pp. 1–19, 2017. View at Publisher · View at Google Scholar
  • Ingrid Glurich, Gregory Nycz, and Amit Acharya, “Status update on translation of integrated primary dental-medical care delivery for management of diabetic patients,” Clinical Medicine and Research, vol. 15, no. 1-2, pp. 21–32, 2017. View at Publisher · View at Google Scholar
  • Albino Carrizzo, Carmine Izzo, Marco Oliveti, Antonia Alfano, Nicola Virtuoso, Mario Capunzo, Paola Di Pietro, Mariaconsiglia Calabrese, Eros De Simone, Sebastiano Sciarretta, Giacomo Frati, Serena Migliarino, Antonio Damato, Mariateresa Ambrosio, Francesco De Caro, and Carmine Vecchione, “The Main Determinants of Diabetes Mellitus Vascular Complications: Endothelial Dysfunction and Platelet Hyperaggregation,” International Journal of Molecular Sciences, vol. 19, no. 10, pp. 2968, 2018. View at Publisher · View at Google Scholar
  • F. Mayyas, “Cardiac effects of cigarette tobacco smoking in rat model of diabetes,” Life Sciences, 2018. View at Publisher · View at Google Scholar
  • Dharmender Malik, Bhagwant Rai Mittal, Ashwani Sood, Madan Parmar, Komalpreet Kaur, and Ajay Bahl, “Prognostic value of left ventricular mechanical dyssynchrony indices in long-standing type II diabetes mellitus with normal perfusion and left ventricular systolic functions on SPECT-MPI,” Journal of Nuclear Cardiology, 2018. View at Publisher · View at Google Scholar
  • José Carlos Arévalo-Lorido, Juana Carretero Gómez, Ricardo Gómez Huelgas, Dolores García de Lucas, Lourdes Mateos Polo, José Manuel Varela Aguilar, and Javier Ena Muñoz, “Lowering Blood Pressure with the Combination of a Sodium-Glucose Cotransporter 2 Inhibitor and a Glucagon-like Peptide-1 Receptor Agonist in Type 2 Diabetic Patients: A Clinical Evidence,” High Blood Pressure & Cardiovascular Prevention, 2018. View at Publisher · View at Google Scholar
  • Xuejing Li, Suhui Qie, Xianying Wang, Yingying Zheng, Yang Liu, and Guoqiang Liu, “The safety and efficacy of once-weekly glucagon-like peptide-1 receptor agonist semaglutide in patients with type 2 diabetes mellitus: a systemic review and meta-analysis,” Endocrine, 2018. View at Publisher · View at Google Scholar
  • Kazuyoshi Shigehara, Hiroyuki Konaka, Yuki Kato, Masashi Iijima, Kazufumi Nakashima, Shohei Kawaguchi, Takahiro Nohara, Kouji Izumi, Mikio Namiki, and Atsushi Mizokami, “Effect of testosterone replacement therapy on sexual function and glycemic control among hypogonadal men with type 2 diabetes mellitus,” International Journal of Impotence Research, 2018. View at Publisher · View at Google Scholar
  • Nicholas E. Buglak, Wulin Jiang, and Edward S.M. Bahnson, “Cinnamic aldehyde inhibits vascular smooth muscle cell proliferation and neointimal hyperplasia in Zucker Diabetic Fatty rats,” Redox Biology, 2018. View at Publisher · View at Google Scholar
  • Constantine E Kosmas, Delia Silverio, Christiana Tsomidou, Maria D Salcedo, Peter D Montan, and Eliscer Guzman, “The Impact of Insulin Resistance and Chronic Kidney Disease on Inflammation and Cardiovascular Disease,” Clinical Medicine Insights: Endocrinology and Diabetes, vol. 11, pp. 117955141879225, 2018. View at Publisher · View at Google Scholar
  • Mequanent Kassa Birarra, and Dessalegn Asmelashe Gelayee, “Metabolic syndrome among type 2 diabetic patients in Ethiopia: a cross-sectional study,” BMC Cardiovascular Disorders, vol. 18, no. 1, 2018. View at Publisher · View at Google Scholar
  • Colin Gerard Egan, Cecilia Fondelli, Enrico Pierantozzi, Giovanni Tripepi, Francesco Dotta, and Vincenzo Sorrentino, “Putative endothelial progenitor cells predict long-term mortality in type-2 diabetes,” Endocrine, 2018. View at Publisher · View at Google Scholar
  • Devavrata Sahu, and Sudha Vidyasagar, “Clinical and angiographic profile of early-onset type 2 diabetes mellitus in acute coronary syndrome,” International Journal of Diabetes in Developing Countries, 2018. View at Publisher · View at Google Scholar
  • James E. Frampton, “Empagliflozin: A Review in Type 2 Diabetes,” Drugs, 2018. View at Publisher · View at Google Scholar
  • Jung-In Kim, Jeong-A Yun, Yoo-Kyung Jeong, and Hee-Jin Baek, “Hypoglycemic and hypolipidemic effects of samnamul (shoot of Aruncus dioicus var. kamtschaticus Hara) in mice fed a high-fat/high-sucrose diet,” Food Science and Biotechnology, 2018. View at Publisher · View at Google Scholar
  • Fu-Shun Yen, Jen-Huai Chiang, Chun-Wei Pan, Boniface J. Lin, James Cheng-Chung Wei, and Chih-Cheng Hsu, “Cardiovascular outcomes of dipeptidyl peptidase-4 inhibitors in patients with type 2 diabetes on insulin therapy,” Diabetes Research and Clinical Practice, vol. 140, pp. 279–287, 2018. View at Publisher · View at Google Scholar
  • Anoja Priyadarshani Attanayake, Kamani Ayoma Perera Wijewardana Jayatilaka, Lakmini Kumari Boralugoda Mudduwa, and Chitra Pathirana, “Biochemical and Histological Evaluation of Three Selected Medicinal Plant Extracts of Sri Lankan Origin on Dyslipidemia and Oxidative Stress in Alloxan Induced Diabetic Rats,” Journal of Botany, vol. 2018, pp. 1–8, 2018. View at Publisher · View at Google Scholar
  • Yan-Fei Jia, Qian Feng, Zheng-Yan Ge, Ying Guo, Fang Zhou, Kai-Shu Zhang, Xiao-Wei Wang, Wen-Hong Lu, Xiao-Wei Liang, and Yi-Qun Gu, “Obesity impairs male fertility through long-term effects on spermatogenesis,” BMC Urology, vol. 18, no. 1, 2018. View at Publisher · View at Google Scholar
  • Tatsuya Fukuda, Ryotaro Bouchi, Takato Takeuchi, Kazutaka Tsujimoto, Isao Minami, Takanobu Yoshimoto, and Yoshihiro Ogawa, “Sarcopenic obesity assessed using dual energy X-ray absorptiometry (DXA) can predict cardiovascular disease in patients with type 2 diabetes: a retrospective observational study,” Cardiovascular Diabetology, vol. 17, no. 1, 2018. View at Publisher · View at Google Scholar
  • Peng Liu, Liang Peng, Haojun Zhang, Patrick Ming-Kuen Tang, Tingting Zhao, Meihua Yan, Hailing Zhao, Xiaoru Huang, Huiyao Lan, and Ping Li, “Tangshen Formula Attenuates Diabetic Nephropathy by Promoting ABCA1-Mediated Renal Cholesterol Efflux in db/db Mice,” Frontiers in Physiology, vol. 9, 2018. View at Publisher · View at Google Scholar
  • Nur Afizah Yusoff, Norsyahida Mohd Fauzi, Sharifah Niza Mohamad Nasir, Fatin Farhana Jubaidi, Satirah Zainalabidin, Nur Liyana Mohammed Yusof, and Siti Balkis Budin, “Hibiscus sabdariffa (Roselle) polyphenol-rich extract prevents the aortic oxidative damage in type 1 diabetic rats,” Jurnal Teknologi, vol. 80, no. 2, pp. 1–8, 2018. View at Publisher · View at Google Scholar
  • C. Itsiopoulos, W. Marx, H.L. Mayr, O.A. Tatucu-Babet, S.R. Dash, E.S. George, G.L. Trakman, J.T. Kelly, C.J. Thomas, and L. Brazionis, “The role of omega-3 polyunsaturated fatty acid supplementation in the management of type 2 diabetes mellitus: A narrative review,” Journal of Nutrition & Intermediary Metabolism, 2018. View at Publisher · View at Google Scholar
  • Nina M. Pollak, Matthew Hoffman, Ira J. Goldberg, and Konstantinos Drosatos, “Krüppel-Like Factors,” JACC: Basic to Translational Science, vol. 3, no. 1, pp. 132–156, 2018. View at Publisher · View at Google Scholar
  • Ibrahim Al-Zakwani, Fatma Al-Mahruqi, Khalid Al-Rasadi, Abdullah Shehab, Wael Al Mahmeed, Mohammed Arafah, Ali T. Al-Hinai, Omer Al Tamimi, Mahmoud Al Awadhi, and Raul D. Santos, “Sex disparity in the management and outcomes of dyslipidemia of diabetic patients in the Arabian Gulf: findings from the CEPHEUS study,” Lipids in Health and Disease, vol. 17, no. 1, 2018. View at Publisher · View at Google Scholar
  • Deborah Hinnen, “Overview of the burden of illness and the role of once-weekly glucagon-like peptide-1 receptor agonist therapy in type 2 diabetes,” Journal of the American Association of Nurse Practitioners, vol. 30, pp. S4–S11, 2018. View at Publisher · View at Google Scholar
  • Xiangyang Cheng, Jing Hu, Ya Wang, Hongwei Ye, Xiaohong Li, Qin Gao, and Zhenghong Li, “Effects of Dexmedetomidine Postconditioning on Myocardial Ischemia/Reperfusion Injury in Diabetic Rats: Role of the PI3K/Akt-Dependent Signaling Pathway,” Journal of Diabetes Research, vol. 2018, pp. 1–10, 2018. View at Publisher · View at Google Scholar
  • Abdelnaby Khalyfa, and David Gozal, “Connexins and Atrial Fibrillation in Obstructive Sleep Apnea,” Current Sleep Medicine Reports, 2018. View at Publisher · View at Google Scholar
  • Franziska Ferk, Michael Kundi, Helmut Brath, Thomas Szekeres, Halh Al-Serori, Miroslav Mišík, Philipp Saiko, Rodrig Marculescu, Karl-Heinz Wagner, and Siegfried Knasmueller, “Gallic Acid Improves Health-Associated Biochemical Parameters and Prevents Oxidative Damage of DNA in Type 2 Diabetes Patients: Results of a Placebo-Controlled Pilot Study,” Molecular Nutrition & Food Research, pp. 1700482, 2018. View at Publisher · View at Google Scholar
  • Lili Zhang, Xiaoyan Wang, Yan Wu, Xiangru Lu, Peter Chidiac, Guoping Wang, and Qingping Feng, “Maternal diabetes up-regulates NOX2 and enhances myocardial ischaemia/reperfusion injury in adult offspring,” Journal of Cellular and Molecular Medicine, 2018. View at Publisher · View at Google Scholar
  • Christian Obirikorang, Yaa Obirikorang, Emmanuel Acheampong, Enoch Odame Anto, Emmanuel Toboh, Evans Adu Asamoah, Bright Amakwaa, Emmanuella Nsenbah Batu, and Peter Brenya, “Association of Wrist Circumference and Waist-to-Height Ratio with Cardiometabolic Risk Factors among Type II Diabetics in a Ghanaian Population,” Journal of Diabetes Research, vol. 2018, pp. 1–11, 2018. View at Publisher · View at Google Scholar
  • Francisco Javier Martinez-Martin, and Margarita SaizSatjes, “Manidipine: An antihypertensive drug with positive effects on metabolic parameters and adrenergic tone in patients with diabetes,” Drugs in Context, vol. 7, 2018. View at Publisher · View at Google Scholar