Antioxidant Treatment Reverts Increased Arterial Basal Tone and Oxidative Stress in Nephrectomized (5/6) Hypertensive Rats

Table 1

Clinical characteristics of rats.

	Rat
	SR; (𝑛=7)	NefR; (𝑛=8)	NefR-T; (𝑛=6)
Body weight (g)	226.3±8.4	218.5±4.5	220.5±5.2
Food intake (g/24 hs)	24.7±3.8	18.2±1.8	23.0±3.6
Water intake (mL/24 hs)	22.7±1.6	41.6±4.1 ***	40.8±2.6^†††
Urinary volume (mL/24 hs)	10.7±2.2	28.1±3.7 ***	23.5±2.4^++
Glucose (mg/dL)	80.0 ± 0.1	83.2 ± 1.3	82.1±1.1
Mean arterial pressure (mm Hg)	119±4	169±6 ***	168±10^†††
Heart rate (beats/min)	365±21	353±16	354±15
Creatinine clearance (mL/min)	0.59±0.1	0.11±0.01 ***	0.22±0.04^††,+
Microalbuminuria (mg/24 hs)	6.8±1.2	62.9±9.8 ***	22.1±5.2^†,+++

SR: sham rats; NefR: nefrectomized rats; NefR-T: NefR treated with tempol; ***𝑃<0.001 NefR versus SR; ^†𝑃<0.05, ^††𝑃<0.01, and ^†††𝑃<0.001 NefR-T versus SR; ⁺𝑃<0.05, ⁺⁺𝑃<0.01, and ⁺⁺⁺𝑃<0.001 NefR-T versus NefR. One way ANOVA.