International Journal of Hypertension / 2014 / Article / Tab 4

Research Article

Efficacy and Tolerability of Telmisartan Plus Amlodipine in Asian Patients Not Adequately Controlled on Either Monotherapy or on Low-Dose Combination Therapy

Table 4

Blood pressure goal rate and response rate at weeks 4 and 8 in the three groups (full analysis set).

Nonresponders to A5Nonresponders to T40 or T80 Nonresponders to low-dose T/A
A5
( )
T40/A5 SPC
( )
T80/A5 SPC
( )
T40
( )
T40/A5 SPC
( )
T80
( )
T80/A5 SPC
( )
T40/A5 SPC
( )
T80/A5 SPC
( )

BP < 140/90 mm Hg
Week 4, (%)158 (38.0)155 (58.9)77 (49.7)55 (34.8)97 (63.4)17 (19.8)46 (52.9)61 (54.5)64 (57.1)
Week 8, (%)160 (38.5)163 (62.0)*100 (64.5)59 (37.3)113 (73.9)20 (23.3)59 (67.8)68 (60.7)71 (63.4)

SBP < 140 mm Hg
Week 4, (%)232 (55.8)194 (73.8)103 (66.5)88 (55.7)121 (79.1)37 (43.0)68 (78.2)83 (74.1)86 (76.8)
Week 8, (%)246 (59.1)205 (77.9)*119 (76.8)87 (55.1)113 (86.9)43 (50.0)73 (83.9)90 (80.4)89 (79.5)

DBP < 90 mm Hg
Week 4, (%)211 (50.7)179 (68.1)95 (61.3)67 (42.4)106 (69.3)19 (22.1)49 (56.3)73 (65.2)69 (61.6)
Week 8, (%)206 (49.5)179 (68.1)*112 (72.3)74 (46.8)120 (78.4)23 (26.7)61 (70.1)74 (66.1)78 (69.6)

SBP < 140 or reduction of ≥20 mm Hg**
Week 4, (%)253 (60.8)202 (76.8)124 (80.0)93 (58.9)123 (80.4)37 (43.0)71 (81.6)83 (74.8)86 (76.8)
Week 8, (%)270 (64.9)209 (79.5)*131 (84.5)92 (58.2)137 (89.5)44 (51.2)77 (88.5)92 (82.1)90 (80.4)

DBP < 90 or reduction of ≥10 mm Hg
Week 4, (%)236 (56.7)190 (72.2)108 (69.7)73 (46.2)118 (77.1)21 (24.4)56 (64.4)77 (69.4)70 (62.5)
Week 8, (%)230 (55.3)196 (74.5)*124 (80.0)79 (50.0)130 (85.0)26 (30.2)70 (80.5)76 (67.9)79 (70.5)

The number of patients included in this analysis may differ from those of the individual study publications, due to differences in statistical approach for the individual studies.
*The data are for the 6 weeks’ duration when patients were on T40/A5 therapy and do not include the 2 weeks when patients were on T20/A5 therapy; **in A5 nonresponder study 2, SBP response was defined as (<140 mmHg and/or reduction from baseline ≥15 mmHg).
A5: amlodipine 5 mg; BP: blood pressure; DBP: diastolic blood pressure; SBP: systolic blood pressure; SPC: single-pill combination; T20: telmisartan 20 mg; T40: telmisartan 40 mg; T80: telmisartan 80 mg; T/A: telmisartan plus amlodipine.