Table of Contents Author Guidelines Submit a Manuscript
International Journal of Hypertension
Volume 2014 (2014), Article ID 565212, 8 pages
http://dx.doi.org/10.1155/2014/565212
Research Article

Long-Term Effect of an Aqueous Fraxinus excelsior L. Seed Extract in Spontaneously Hypertensive Rats

1Departmento de Farmacología, Facultad de Medicina, Universidad de Complutense, Avenida Complutense s/n, 28040 Madrid, Spain
2Instituto de Investigación en Ciencias de Alimentación (CIAL) (CSIC-UAM), C/Nicolás Cabrera, 9, 28049 Madrid, Spain

Received 20 September 2013; Accepted 10 January 2014; Published 18 February 2014

Academic Editor: Tomohiro Katsuya

Copyright © 2014 Noemi López-Carreras et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C.-Y. Kwan, “Vascular effects of selected antihypertensive drugs derived from traditional medicinal herbs,” Clinical and Experimental Pharmacology and Physiology, vol. 22, no. 1, pp. S297–S299, 1995. View at Google Scholar · View at Scopus
  2. E. U. Etuk, “A review of medicinal plants with hypotensive or antihypertensive effects,” Journal of Medical Sciences, vol. 6, no. 6, pp. 894–900, 2006. View at Publisher · View at Google Scholar · View at Scopus
  3. O. Burta, F. Tirlea, O. L. Burta, and S. M. Qadri, “Phytotherapy in cardiovascular diseases: from ethnomedicine to evidence based medicine,” Journal of Biological Sciences, vol. 8, no. 2, pp. 242–247, 2008. View at Publisher · View at Google Scholar · View at Scopus
  4. A. Peterson, “Iridoids in Tahitian Noni bioactive beverages are found to be extremely stable,” 2000, http://www.prweb.com/releases/Tahitian-Noni/Iridoids/prweb3663324.htm.
  5. F. Visioli, A. Poli, and C. Gall, “Antioxidant and other biological activities of phenols from olives and olive oil,” Medicinal Research Reviews, vol. 22, no. 1, pp. 65–75, 2002. View at Publisher · View at Google Scholar · View at Scopus
  6. B. Dinda, S. Debnath, and R. Banik, “Naturally occurring iridoids and secoiridoids,” Chemical and Pharmaceutical Bulletin, vol. 59, no. 7, pp. 803–833, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. R. A. Ribeiro, M. M. Fiuza de Melo, F. de Barros, C. Gomes, and G. Trolin, “Acute antihypertensive effect in conscious rats produced by some medicinal plants used in the state of São Paulo,” Journal of Ethnopharmacology, vol. 15, no. 3, pp. 261–269, 1986. View at Google Scholar · View at Scopus
  8. M. T. Khayyal, M. A. El-Ghazaly, D. M. Abdallah, N. N. Nassar, S. N. Okpanyi, and M.-H. Kreuter, “Blood pressure lowering effect of an olive leaf extract (Olea europaea) in L-NAME induced hypertension in rats,” Arzneimittelforschung, vol. 52, no. 11, pp. 797–802, 2002. View at Google Scholar · View at Scopus
  9. M. Eddouks, M. Maghrani, N.-A. Zeggwagh, M. Haloui, and J.-B. Michel, “Fraxinus excelsior L. evokes a hypotensive action in normal and spontaneously hypertensive rats,” Journal of Ethnopharmacology, vol. 99, no. 1, pp. 49–54, 2005. View at Publisher · View at Google Scholar · View at Scopus
  10. K. He, M. Roller, A. Bily, N. Bai, J. Dikansky, and A. Ibarra, “Extract of Fraxinus excelsior seeds and therapeutic applications therefor,” PCT/US2008/082524.
  11. P. Visen, B. Saraswat, A. Visen et al., “Acute effects of Fraxinus excelsior L. seed extract on postprandial glycemia and insulin secretion on healthy volunteers,” Journal of Ethnopharmacology, vol. 126, no. 2, pp. 226–232, 2009. View at Publisher · View at Google Scholar · View at Scopus
  12. A. Ibarra, N. Bai, K. He et al., “Fraxinus excelsior seed extract FraxiPure limits weight gains and hyperglycemia in high-fat diet-induced obese mice,” Phytomedicine, vol. 18, no. 6, pp. 479–485, 2011. View at Publisher · View at Google Scholar · View at Scopus
  13. N. López-Carreras, S. Fernández-Vallinas, M. Miguel, and A. Aleixandre, “Fraxinus excelsior L. seed extract in spontaneously hypertensive rats,” Food Research International, vol. 53, no. 1, pp. 81–87, 2013. View at Google Scholar
  14. J. Flanagan, M. Meyer, M. A. Pasamar et al., “Safety evaluation and nutritional composition of a Fraxinus excelsior seed extract, FraxiPure,” Food and Chemical Toxicology, vol. 53, pp. 10–17, 2013. View at Publisher · View at Google Scholar
  15. R. F. Furchgott and J. V. Zawadzki, “The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine,” Nature, vol. 288, no. 5789, pp. 373–376, 1980. View at Google Scholar · View at Scopus
  16. R. F. Furchgott, “Endothelium-derived relaxing factor: discovery, early studies, and identification as nitric oxide,” Bioscience Reports, vol. 19, no. 4, pp. 235–251, 1999. View at Google Scholar · View at Scopus
  17. R. D. Buñag, “Validation in awake rats of a tail-cuff method for measuring systolic pressure,” Journal of Applied Physiology, vol. 34, no. 2, pp. 279–282, 1973. View at Google Scholar · View at Scopus
  18. M. A. Manso, M. Miguel, J. Even, R. Hernández, A. Aleixandre, and R. López-Fandiño, “Effect of the long-term intake of an egg white hydrolysate on the oxidative status and blood lipid profile of spontaneously hypertensive rats,” Food Chemistry, vol. 109, no. 2, pp. 361–367, 2008. View at Publisher · View at Google Scholar · View at Scopus
  19. D. K. Vadyal, H. Lata, and A. P. Dadhich, “Animal models of hypertension and effect of drugs,” Indian Journal of Pharmacology, vol. 35, no. 6, pp. 349–362, 2003. View at Google Scholar · View at Scopus
  20. K. Okamoto and K. Aoki, “Development of a strain of spontaneously hypertensive rats,” Japanese Circulation Journal, vol. 27, pp. 282–293, 1963. View at Google Scholar · View at Scopus
  21. A. Cabassi, S. Vinci, M. Calzolari, G. Bruschi, A. Cavatorta, and A. Borghetti, “The relationship between regional sympathetic activity and the onset of arterial hypertension in spontaneously hypertensive rats,” Cardiologia, vol. 42, no. 4, pp. 393–396, 1997. View at Google Scholar · View at Scopus
  22. M. Miguel, B. Muguerza, E. Sánchez et al., “Changes in arterial blood pressure in hypertensive rats caused by long-term intake of milk fermented by Enterococcus faecalis CECT 5728,” British Journal of Nutrition, vol. 94, no. 1, pp. 36–43, 2005. View at Publisher · View at Google Scholar · View at Scopus
  23. M. Miguel, R. López-Fandiño, M. Ramos, and M. A. Aleixandre, “Long-term antihypertensive effect of egg white treated with pepsin in hypertensive rats,” Life Sciences, vol. 78, pp. 2960–2926, 2006. View at Publisher · View at Google Scholar
  24. E. Cienfuegos-Jovellanos, M. M. Quiñones, B. Muguerza, L. Moulay, M. Miguel, and A. Aleixandre, “Antihypertensive effect of a polyphenol-rich cocoa powder industrially processed to preserve the original flavonoids of the cocoa beans,” Journal of Agricultural and Food Chemistry, vol. 57, no. 14, pp. 6156–6162, 2009. View at Publisher · View at Google Scholar · View at Scopus
  25. M. Sipola, P. Finckenberg, J. Santisteban, R. Korpela, H. Vapaatalo, and M.-L. Nurminen, “Long-term intake of milk peptides attenuates development of hypertension in spontaneously hypertensive rats,” Journal of Physiology and Pharmacology, vol. 52, no. 4, pp. 745–754, 2001. View at Google Scholar · View at Scopus
  26. M. Quiñones, D. Sánchez, B. Muguerza et al., “Long-term intake of CocoanOX attenuates the development of hypertension in spontaneously hypertensive rats,” Food Chemistry, vol. 122, no. 4, pp. 1013–1019, 2010. View at Publisher · View at Google Scholar · View at Scopus
  27. C. K. Kost, B. R. Rominski, W. A. Herzer, E. K. Jackson, and S. P. Tofovic, “Persistent improvement of cardiovascular risk factors in spontaneously hypertensive rats following early short-term captopril treatment,” Clinical and Experimental Hypertension, vol. 22, no. 2, pp. 127–143, 2000. View at Publisher · View at Google Scholar · View at Scopus
  28. L. Chow, M. de Gasparo, and N. Levens, “Blockade of angiotensin converting enzyme but not of angiotensin AT1 receptors improves glucose tolerance,” European Journal of Pharmacology, vol. 319, no. 1, pp. 77–83, 1997. View at Publisher · View at Google Scholar · View at Scopus
  29. C. C. Barney, M. J. Katovich, and M. J. Fregly, “The effect of acute administration of an angiotensin converting enzyme inhibitor, captopril (SQ 14,225), on experimentally induced thirsts in rats,” Journal of Pharmacology and Experimental Therapeutics, vol. 212, no. 1, pp. 53–57, 1980. View at Google Scholar · View at Scopus
  30. M. J. Fregly and N. E. Rowland, “Bradykinin-induced dipsogenesis in captopril-treated rats,” Brain Research Bulletin, vol. 26, no. 1, pp. 169–172, 1991. View at Publisher · View at Google Scholar · View at Scopus
  31. C. Kitiyakara and C. S. Wilcox, “Antioxidants for hypertension,” Current Opinion in Nephrology and Hypertension, vol. 7, no. 5, pp. 531–538, 1998. View at Publisher · View at Google Scholar · View at Scopus
  32. Y. Li, Y. Zuo, and W.-J. Sun, “Study on antioxidant activity of two major secoiridoid glucosides in the fruits of Ligustrum lucidum Ait,” Zhong Yao Cai, vol. 30, no. 5, pp. 543–546, 2007. View at Google Scholar · View at Scopus
  33. G. Fu, F. C. Ip, H. Pang, and N. Y. Ip, “New secoiridoid glucosides from ligustrum lucidum induce erk and creb phosphorylation in cultured cortical neurons,” Planta Medica, vol. 76, no. 10, pp. 998–1003, 2010. View at Publisher · View at Google Scholar · View at Scopus
  34. V. Roginsky and E. A. Lissi, “Review of methods to determine chain-breaking antioxidant activity in food,” Food Chemistry, vol. 92, no. 2, pp. 235–254, 2005. View at Publisher · View at Google Scholar · View at Scopus
  35. R. Schneider, H. Iscovitz, Z. Ilan, K. Bernstein, M. Gros, and A. Iaina, “Oxygen free radical scavenger system intermediates in essential hypertensive patients before and immediately after sublingual captopril administration,” Israel Journal of Medical Sciences, vol. 26, no. 9, pp. 491–495, 1990. View at Google Scholar · View at Scopus
  36. D. Bagchi, R. Prasad, and D. K. Das, “Direct scavening of free radicals by captopril, an angiotensin converting enzyme inhibitor,” Biochemical and Biophysical Research Communications, vol. 158, no. 1, pp. 52–57, 1989. View at Google Scholar · View at Scopus
  37. S. P. Andreoli, “Captopril scavenges hydrogen peroxide and reduces, but does not eliminate, oxidant-induced cell injury,” American Journal of Physiology, vol. 264, pp. F120–F127, 1993. View at Google Scholar · View at Scopus