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International Journal of Hypertension
Volume 2014, Article ID 712169, 5 pages
http://dx.doi.org/10.1155/2014/712169
Research Article

The Flavin-Containing Monooxygenase 3 Gene and Essential Hypertension: The Joint Effect of Polymorphism E158K and Cigarette Smoking on Disease Susceptibility

1Department of Biology, Medical Genetics and Ecology, Kursk State Medical University, Karl Marx Street, 3, Kursk 305041, Russia
2Department of Medical Biological Disciplines, Belgorod State National Research University, Pobeda Street, 85, Belgorod 308015, Russia

Received 11 June 2014; Revised 1 August 2014; Accepted 17 August 2014; Published 27 August 2014

Academic Editor: Franco Veglio

Copyright © 2014 Olga Bushueva et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. M. Briones and R. M. Touyz, “Oxidative stress and hypertension: current concepts,” Current Hypertension Reports, vol. 12, no. 2, pp. 135–142, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. N. F. Renna, “Oxidative stress, vascular remodeling, and vascular inflammation in hypertension,” International Journal of Hypertension, vol. 2013, Article ID 710136, 2 pages, 2013. View at Publisher · View at Google Scholar
  3. S. K. Krueger and D. E. Williams, “Mammalian flavin-containing monooxygenases: structure/function, genetic polymorphisms and role in drug metabolism,” Pharmacology and Therapeutics, vol. 106, no. 3, pp. 357–387, 2005. View at Publisher · View at Google Scholar · View at Scopus
  4. J. R. Cashman, B. R. Akerman, S. M. Forrest, and E. P. Treacy, “Population-specific polymorphisms of the human FMO3 gene: significance for detoxication,” Drug Metabolism and Disposition, vol. 28, no. 2, pp. 169–173, 2000. View at Google Scholar · View at Scopus
  5. B. R. Akerman, H. Lemass, L. M. L. Chow et al., “Trimethylaminuria is caused by mutations of the FMO3 gene in a North American cohort,” Molecular Genetics and Metabolism, vol. 68, no. 1, pp. 24–31, 1999. View at Publisher · View at Google Scholar · View at Scopus
  6. C. Dolan, D. C. Shields, A. Stanton et al., “Polymorphisms of the flavin containing monooxygenase 3 (FMO3) gene do not predispose to essential hypertension in Caucasians,” BMC Medical Genetics, vol. 6, article 41, 2005. View at Publisher · View at Google Scholar · View at Scopus
  7. A. V. Polonikov, V. P. Ivanov, M. A. Solodilova et al., “A common polymorphism G-50T in cytochrome P450 2J2 gene is associated with increased risk of essential hypertension in a Russian population,” Disease Markers, vol. 24, no. 2, pp. 119–126, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. I. N. Sorokina, M. I. Churnosov, and E. V. Balanovskaia, “The gene pool of the Belgorod region population: description of the “genetic landscape” of 22 district populations,” Genetika, vol. 45, no. 5, pp. 700–710, 2009. View at Google Scholar · View at Scopus
  9. E. K. Vialykh, M. A. Solodilova, O. Y. Bushueva, I. V. Bulgakova, and A. V. Polonikov, “Catalase gene polymorphism is associated with increased risk of cerebral stroke in hypertensive patients,” Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova, vol. 112, no. 8, part 2, pp. 3–7, 2012. View at Google Scholar · View at Scopus
  10. E. P. Treacy, B. R. Akerman, L. M. L. Chow et al., “Mutations of the flavin-containing monooxygenase gene (FMO3) cause trimethylaminuria, a defect in detoxication,” Human Molecular Genetics, vol. 7, no. 5, pp. 839–845, 1998. View at Publisher · View at Google Scholar · View at Scopus
  11. R. M. Touyz, “Oxidative stress and vascular damage in hypertension,” Current Hypertension Reports, vol. 2, no. 1, pp. 98–105, 2000. View at Publisher · View at Google Scholar · View at Scopus
  12. J. de Champlain, R. Wu, H. Girouard et al., “Oxidative stress in hypertension,” Clinical and Experimental Hypertension, vol. 26, no. 7-8, pp. 593–601, 2004. View at Publisher · View at Google Scholar · View at Scopus
  13. N. D. Vaziri and B. Rodríguez-Iturbe, “Mechanisms of disease: oxidative stress and inflammation in the pathogenesis of hypertension,” Nature Reviews Nephrology, vol. 2, no. 10, pp. 582–593, 2006. View at Publisher · View at Google Scholar
  14. A. Virdis, C. Giannarelli, M. F. Neves, S. Taddei, and L. Ghiadoni, “Cigarette smoking and hypertension,” Current Pharmaceutical Design, vol. 16, no. 23, pp. 2518–2525, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. M. A. H. Talukder, W. M. Johnson, S. Varadharaj et al., “Chronic cigarette smoking causes hypertension, increased oxidative stress, impaired NO bioavailability, endothelial dysfunction, and cardiac remodeling in mice,” The American Journal of Physiology—Heart and Circulatory Physiology, vol. 300, no. 1, pp. H388–H396, 2011. View at Publisher · View at Google Scholar · View at Scopus