The Flavin-Containing Monooxygenase 3 Gene and Essential Hypertension: The Joint Effect of Polymorphism E158K and Cigarette Smoking on Disease Susceptibility

Table 2

Allele and genotype frequencies for polymorphism E158K of the FMO3 gene in patients with essential hypertension (EH) and controls in two Russian populations.

FMO3 allele and genotype frequencies	EH patients; (%)^I	Controls; (%)^I	Chi-square; ()^II	OR; (95% CI)
Discovery cohort (Kursk region), (1 362 EH patients and 843 healthy controls)
Alleles
158E; 158K	1 474 (54.1); 1 250 (45.9)	960 (56.2); 748 (43.8)	1.86 (0.17)	1.09 (0.96–1.23)^III
Genotypes
158EE; 158EK; 158KK	423 (31.1); 628 (46.1); 311 (22.8)	260 (30.4); 440 (51.5); 154 (18.0)		1.35 (1.08–1.69)^III; 1.36 (1.09–1.69)^IV
Replication population (Belgorod region), (357 EH patients and 422 healthy controls)
Alleles
158E; 158K	365 (51.1); 349 (48.9)	468 (55.5); 476 (44.5)	2.91 (0.09)	1.19 (0.97–1.45)^III
Genotypes
158EE; 158EK; 158KK	105 (29.4); 155 (43.4); 97 (27.2)	127 (30.1); 214 (50.7); 81 (19.2)		1.57 (1.12–2.00)^III; 1.54 (1.07–1.89)^IV

^IAbsolute number and percentage of individuals with particular allele/genotype.
^IIPearson’s chi-square statistics and values.
^IIIOdds ratio (95% confidence interval) for association between 158KK genotype and EH risk.
^IVOdds ratio (95% confidence interval) for association between 158KK genotype and EH risk adjusted for gender and age.
*Means a significant association.