CYP17A1 and Blood Pressure Reactivity to Stress in Adolescence
Table 2
Associations of the CYP17A1 locus (rs10786718#) and studied BP phenotypes.
Males
Females
Beta (SE)
AA
GA
GG
value
Beta (SE)
GG
GA
AA
value
Mean (SD)
Mean (SD)
Mean (SD)
Mean (SD)
Mean (SD)
Mean (SD)
(A) SBP
Reactivity to standing
−0.17 (0.70)
8.5 (1.5)
11.8 (0.8)
10.1 (0.6)
0.81
0.92 (0.66)
9.5 (0.5)
9.4 (0.7)
7.6 (1.4)
0.16
Poststanding resting*
0.12 (0.98)
120.9 (2.0)
125.7 (1.0)
123.5 (0.8)
0.90
−0.17 (0.85)
118.7 (0.7)
119.8 (0.9)
117.9 (1.9)
0.85
Reactivity to math
3.40 (0.76)
12.4 (1.6)
17.3 (0.8)
20.0 (0.6)
8.3E − 06
0.48 (0.75)
16.5 (0.6)
16.8 (0.8)
14.4 (1.6)
0.52
Postmath resting*
0.38 (0.95)
125.6 (2.0)
129.1 (1.0)
127.8 (0.8)
0.69
0.31 (0.90)
124.0 (0.7)
123.9 (1.0)
123.6 (2.0)
0.73
(B) DBP
Reactivity to standing*
0.09 (0.42)
9.2 (0.9)
10.5 (0.5)
10.1 (0.4)
0.83
0.23 (0.42)
10.4 (0.4)
10.5 (0.5)
9.3 (0.9)
0.58
Poststanding resting
−0.07 (0.68)
77.3 (1.5)
80.6 (0.7)
78.9 (0.6)
0.92
0.44 (0.65)
75.3 (0.5)
76.5 (0.7)
72.5 (1.4)
0.50
Reactivity to math*
1.85 (0.42)
6.6 (0.9)
10.5 (0.4)
11.4 (0.4)
1.1E − 05
0.24 (0.42)
10.5 (0.4)
10.5 (0.5)
9.4 (0.9)
0.57
Postmath resting
0.03 (0.69)
80.6 (1.5)
83.0 (0.7)
81.9 (0.6)
0.97
0.30 (0.66)
79.3 (0.5)
79.7 (0.7)
77.8 (1.5)
0.65
Beta (SE = standard error) is the effect size on BP in mm Hg, per 1 copy of the index allele (G) based on an additive model adjusted for age and height. *Model was additionally adjusted for initial BP.
#Minor allele (A) frequencies in males and females are 0.27 and 0.26, respectively.
