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International Journal of Hypertension
Volume 2015 (2015), Article ID 979631, 7 pages
Research Article

Renin-Angiotensin System Genes Polymorphisms and Essential Hypertension in Burkina Faso, West Africa

1Centre de Recherche Biomoléculaire Pietro Annigoni (CERBA), BP 364, Ouagadougou 01, Burkina Faso
2Laboratoire de Biologie et Génétique Moléculaires (LABIOGENE), Université de Ouagadougou, BP 7021, Ouagadougou 03, Burkina Faso
3Ecole Supérieure des Techniques Biologiques et Alimentaires (ESTBA-UL), Université de Lomé, BP 1515, Togo
4Service de Cardiologie, CHU-Yalgado Ouédraogo, BP 7022, Ouagadougou 03, Burkina Faso
5Centre Médical Saint Camille (CMSC), BP 444, Ouagadougou 09, Burkina Faso
6Laboratoire de Biologie Moléculaire et Cellulaire (LABMC), Université des Sciences et Techniques de Masuku (USTM), BP 943, Franceville, Gabon

Received 7 May 2015; Accepted 8 July 2015

Academic Editor: Tomohiro Katsuya

Copyright © 2015 Daméhan Tchelougou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. This study aimed to investigate the association between three polymorphisms of renin-angiotensin system and the essential hypertension in the population of Burkina Faso. Methodology. This was a case-control study including 202 cases and 204 matched controls subjects. The polymorphisms were identified by a classical and a real-time PCR. Results. The AGT 235M/T and AT1R 1166A/C polymorphisms were not associated with the hypertension while the genotype frequencies of the ACE I/D polymorphism between patients and controls (DD: 66.83% and 35.78%, ID: 28.22% and 50.98%, II: 4.95% and 13.24%, resp.) were significantly different (p < 10−4). The genotype DD of ACE gene (OR = 3.40, p < 0.0001), the increasing age (OR = 3.83, p < 0.0001), obesity (OR = 4.84, p < 0.0001), dyslipidemia (OR = 3.43, p = 0.021), and alcohol intake (OR = 2.76, p < 0.0001) were identified as the independent risk factors for hypertension by multinomial logistic regression. Conclusion. The DD genotype of the ACE gene is involved in susceptibility to hypertension. Further investigations are needed to better monitor and provide individualized care for hypertensive patients.