International Journal of Hypertension / 2016 / Article / Tab 1

Research Article

The Association between ESR and CRP and Systemic Hypertension in Sarcoidosis

Table 1

Demographic and clinical characteristics of the sarcoidosis cohort.

All subjects
()
Sarcoidosis with HTN ()Sarcoidosis without HTN () value

Baseline demographics and comorbidities
Age (years, mean ± SD)53.4 ± 9.456 ± 9.250.6 ± 8.90.002
Female sex% ()76.9% (83)76.4% (42)77.4% (41)0.902
BMI (Kg/m2, mean ± SD)31.9 ± 833.5 ± 8.230.2 ± 7.40.037
Duration of sarcoidosis (y, mean ± SD)12.2 ± 9.114.3 ± 9.810 ± 7.90.014
African American% ()70.4% (76)89.1% (49)50.9% (27)0.0001
Diabetes% ()31.1% (33)38.2% (21)23.5% (12)0.106
Dyslipidemia% ()24.3% (26)33.3% (18)15.1% (8)0.031
CKD% ()3.7% (4)5.5% (3)1.9% (1)0.348
PCI or CABG% ()1.9% (2)1.8% (1)1.9% (1)0.979
Atrial fibrillation% ()5.6% (6)7.3% (4)3.8% (2)0.435
CHF% ()6.6% (7)9.3% (5)3.8% (2)0.276
Pulmonary hypertension% ()26.2% (28)37% (20)15.1% (8)0.012
Rheumatoid arthritis% ()3.7% (4)5.5% (3)1.9% (1)0.348
Asthma% ()26.2% (28)27.8% (15)24.5% (13)0.702
OSA% ()24.3% (28)30.9% (17)17.3% (9)0.105
Dyspnea% ()52.9% (54)62.7% (32)43.1% (22)0.049

Pulmonary function tests and echocardiography
FVC% (mean ± SD)93.2 ± 20.987.7 ± 19.999.4 ± 20.40.008
FEV1% (mean ± SD)88 ± 24.980.5 ± 23.996.7 ± 23.40.002
TLC% (mean ± SD)89.1 ± 15.684.7 ± 1594.1 ± 15.10.005
RV% (mean ± SD)99.4 ± 26.798.4 ± 29.4100.9 ± 22.70.711
DLCO% (mean ± SD)67 ± 20.358.8 ± 18.476.4 ± 18.40.000
EF (mean ± SD)57.8 ± 4.857.1 ± 4.858.6 ± 4.70.108

Treatment
Oral steroid% ()83.5% (86)88% (44)79.2% (42)0.237
DMARD% ()43.9% (47)43.6% (24)44.2% (23)0.951
Methotrexate% ()29.6% (32)25.5% (14)34% (18)0.334
Azathioprine% ()4.7% (5)3.6% (2)5.6% (3)0.620
Lasix% ()17.6% (19)23.6% (13)11.3% (6)0.099
Warfarin% ()2.8% (3)5.5% (3)0% (0)0.129
Statin% ()28.7% (31)38.2% (21)18.9% (10)0.029
ACE or ARB% ()46.7% (50)74.1% (40)18.9% (10)0.0001
Aspirin26.9% (29)34.5% (19)18.9% (10)0.069

PHTN: pulmonary hypertension, BMI: body mass index, CKD: chronic kidney disease, PCI: percutaneous coronary intervention, CABG: coronary artery bypass graft, OSA: obstructive sleep apnea, PASP: pulmonary artery systolic pressure, EF: ejection fraction, ESR: erythrocyte sedimentation rate, CRP: C-reactive protein, DMARD: disease modifying antirheumatic drug, ACE: angiotensin converting enzyme, y: year, m: mean, and SD: standard deviation.

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