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International Journal of Hypertension
Volume 2018, Article ID 8086714, 13 pages
Research Article

Carotid Intima Media Thickness Reference Intervals for a Healthy Argentinean Population Aged 11–81 Years

1Instituto de Investigación en Ciencias de la Salud, UNICEN, CONICET, Tandil, Argentina
2Physiology Department, School of Medicine, Centro Universitario de Investigación, Innovación y Diagnóstico Arterial (CUiiDARTE), Republic University, General Flores 2125, 11800 Montevideo, Uruguay
3PLADEMA, Facultad de Ciencias Exactas, Universidad Nacional del Centro de la Provincia de Buenos Aires, Tandil, Argentina
4Instituto de Medicina Traslacional, Trasplante y Bioingeniería (IMETTyB), Universidad Favaloro-CONICET, Buenos Aires, Argentina

Correspondence should be addressed to Alejandro Diaz; moc.liamg@necinuordnajela

Received 22 November 2017; Revised 29 December 2017; Accepted 15 January 2018; Published 14 February 2018

Academic Editor: Franco Veglio

Copyright © 2018 Alejandro Diaz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Reference intervals (RIs) of carotid intima media thickness (CIMT) from large healthy population are still lacking in Latin America. The aim of this study was to determine CIMT RIs in a cohort of 1012 healthy subjects from Argentina. We evaluated if RIs for males and females and for left and right carotids were necessary. Second, mean and standard deviation (SD) age-related equations were obtained for left, right, and average (left + right)/2) CIMT using parametric regression methods based on fractional polynomials, in order to obtain age-specific percentiles curves. Age-specific percentile curves were obtained. Males showed higher A-CIMT ( mm versus  mm, ) in comparison with females. For males, the equations were as follows: A-CIMT mean = 0.42 + ; A-CIMT SD = 5.9 × 10−2 + . For females, they were as follows: A-CIMT mean = 0.40 + ; A-CIMT SD = 4.67 × 10−2 + . Our study provides the largest database concerning RIs of CIMT in healthy people in Argentina. Specific RIs and percentiles of CIMT for children, adolescents, and adults are now available according to age and gender, for right and left common carotid arteries.