Association of FMO3 Variants with Blood Pressure in the Atherosclerosis Risk in Communities Study
Table 4
Results from low-frequency single-variant analysis of FMO3 with SBP or DBP as outcomes in African Americans.
Variant
MAC
Non-coding/coding allele
Classification
SBP
DBP
Estimate
P-value
95% CI
Estimate
P-value
95% CI
rs369534680
8
G/T
Intronic
2.89
0.70
(-11.58, 17.35)
4.31
0.34
(-4.45, 13.06)
rs12072582
235
G/C
Nonsynonymous
-0.13
0.92
(-2.84, 2.58)
0.20
0.81
(-1.43, 1.84)
rs75904274
11
G/T
Nonsynonymous
-7.16
0.26
(-19.51, 5.19)
-0.68
0.86
(-8.14, 6.77)
rs144283823
31
G/C
Synonymous
3.53
0.35
(-3.85, 10.90)
1.49
0.51
(-2.96, 5.94)
rs1736557
198
G/A
Nonsynonymous
-1.53
0.31
(-4.51, 1.45)
-0.13
0.88
(-1.93, 1.66)
rs2266780
211
A/G
Nonsynonymous
-0.06
0.97
(-3.01, 2.88
-0.57
0.53
(-2.34, 1.21)
rs115908652
42
C/T
Synonymous
3.01
0.36
(-3.43, 9.45)
1.46
0.46
(-2.42, 5.35)
rs148504519
21
C/T
Synonymous
-6.93
0.13
(-15.87, 2.01)
-1.94
0.48
(-7.33, 3.46)
rs28363581
29
T/C
Nonsynonymous
-3.02
0.42
(-10.39, 4.34)
1.42
0.53
(-3.02, 5.86)
rs2066532
67
G/C
Nonsynonymous
-3.32
0.20
(-8.38, 1.73)
-2.01
0.20
(-5.06, 1.04)
rs79553697
66
T/C
Synonymous
1.64
0.51
(-3.25, 6.53)
1.53
0.31
(-1.42, 4.48)
rs200985584
6
G/A
Nonsynonymous
30.90
0.0003
(14.26, 47.53)
13.22
0.01
(3.16, 23.27)
rs61008738
17
C/T
Nonsynonymous
-9.55
0.06
(-19.48, 0.38)
-2.64
0.39
(-8.63, 3.36)
6
AG/A
Frameshift
1.76
0.84
(-14.99, 18.52)
1.32
0.80
(-8.78, 11.43)
SBP, systolic blood pressure; DBP, diastolic blood pressure; MAC, minor allele count; CI, confidence interval. All variants in African Americans with a MAF between 0.1% and 5% were included in this analysis. Chromosome and base pair position in build 37.
