Feasibility of Screening Primary Aldosteronism by Aldosterone-to-Direct Renin Concentration Ratio Derived from Chemiluminescent Immunoassay Measurement: Diagnostic Accuracy and Cutoff Value

Table 2

Detection ranges and sensitivities of angiotensin I, DRC, and PAC measured by RIA and CLIA.

Variable	Detection range	Sensitivity
Angiotensin I (ng/ml)	0.20-12.00	≤0.10
(ng/dL)	0.76-160.00	0.76
DRC (mU/L)	0.52-500.00	0.13
(ng/dL)	3.00-100.00	≤0.97

Plasma renin activity measured by radioimmunoassay was indirectly estimated by efficiency of generating angiotensin I from angiotensinogen. RIA: radioimmunoassay; CLIA: chemiluminescent immunoassay; : plasma aldosterone concentration measured by radioimmunoassay; DRC: direct renin concentration; : plasma aldosterone concentration measured by chemiluminescent immunoassay.