Feasibility of Screening Primary Aldosteronism by Aldosterone-to-Direct Renin Concentration Ratio Derived from Chemiluminescent Immunoassay Measurement: Diagnostic Accuracy and Cutoff Value

Table 5

Sensitivity, specificity, positive predictive value, and negative predictive value of different cutoff values of ARR.

criterion	sensitivity	specificity	+PV	-PV
>6.14	92.31	60.98	20.8	98.6
>6.52	84.62	62.72	20.1	97.3
>16.07	76.92	87.80	41.2	97.2
>25.28	76.92	93.38	56.4	97.3
>27.05	61.54	93.38	50.8	95.6
>33.99	61.54	95.12	58.4	95.7
>40.22	46.15	97.91	71.0	94.2

ARR: aldosterone-to-plasma rennin activity ratio; +PV: positive predictive value; -PV: negative predictive value. ARR is expressed in (ng/dL)/(ng/mL/h). The cutoff value in bold was used in the present study.