A Randomized, Double-Blind, Placebo-Controlled, Multicentre Trial of the Effects of a Shrimp Protein Hydrolysate on Blood Pressure

Table 4

Changes in office blood pressure for all subjects in the ITT population during the 8-week supplementation period.

Group	W 0	W 2	W 4	W 8	Change from; W 0 to W		Change from; W 0 to W		Change from; W 0 to W
					Within-group (p-value)	Between-group p-value	Within-group (p-value)	Between-group p-value	Within-group (p-value)	Between-group p-value
Office SBP (mmHg; mean ± SD)
RPC (n=72)	144.4 ± 6.5	139.9 ± 9.8	139.1 ± 8.5	137.7 ± 9.3	-4.4 ± 9.0	0.031	-5.3 ± 7.7	0.010	-6.7 ± 8.0	0.087
					(p<0.001)		(p<0.001)		(p<0.001)
Placebo (n=72)	147.3 ± 8.3	144.9 ± 9.3	144.2 ± 9.4	142.3 ± 11.4	-2.4 ± 8.4		-3.1 ± 9.3		-5.0 ± 10.8
					(p=0.017)		(p=0.007)		(p<0.001)
Office DBP (mmHg; mean ± SD)
RPC (n=72)	86.9 ± 6.7	85.2 ± 7.2	85.0 ± 7.7	85.2 ± 7.2	-1.7 ± 5.5	0.515	-1.9 ± 7.0	0.081	-1.7 ± 6.5	0.137
					(p=0.010)		(p=0.027)		(p=0.033)
Placebo (n=72)	88.1 ± 8.3	86.6 ± 7.5	87.5 ± 7.0	87.5 ± 8.0	-1.5 ± 6.7		-0.6 ± 6.8		-0.6 ± 7.7
					(p=0.055)		(p=0.422)		(p=0.492)

ANCOVA: analysis of covariance; DBP: diastolic blood pressure; ITT: intention-to-treat; mmHg: millimeter of mercury; RPC: Refined Peptide Concentrate; SBP: systolic blood pressure; SD: standard deviation; W: week
-group comparisons of the changes from W 0 to W 2, W 0 to W 4, and W 0 to W 8 were made using the paired Student t-test. Between-group comparisons of the changes from W 0 to W 2, W 0 to W 4, and W 0 to W 8 were made using ANCOVA with the value at baseline used as the covariate. p≤0.05 was considered statistically significant.