Research Article

Arterial Destiffening Starts Early after Renal Artery Denervation

Table 2

Blood pressure, central haemodynamics and arterial stiffness.

BaselineMonth 1Month 3Month 6Year 1

24-hour ambulatory BP

Mean systolic BP (mm Hg)163 ± 18152 ± 18
(n-21, p=0.009)
151 ± 22 (n-54, p<0.001)149 ± 20 (n-53, p<0.001)152± 17(n-49, p<0.001)
Mean diastolic BP (mm Hg)97 ± 1493 ± 14 (n-21, p=0.28)89 ± 12 (n-54, p<0.001)90 ± 10 (n-53, p<0.001)91± 10 (n-49, p=0.001)
Mean HR (beats/min)71 ± 1070 ± 8 (n-21, p=0.186)70 ± 9 (n-52, p=0.154))70 ± 9 (n-51, p=0.201) 68± 8
(n-48, p=0.242)
Daytime mean systolic BP (mm Hg)168 ± 18156 ± 18 (n-21, p=0.079)153 ± 23 (n-54, p<0.001))152 ± 20 (n-52, p<0.001)155 ± 18 (n-48, p<0.001)
Daytime mean diastolic BP (mm Hg)101 ± 1597 ± 14 (n-21, p=0.284)92 ± 13 (n-54, p<0.001)94 ± 11 (n-52, p<0.001)95 ± 11 (n-48, p=0.001)
Nighttime mean systolic BP (mm Hg)155 ± 21140 ± 20 (n-21, p=0.022)144 ± 25 (n-54, p<0.001)142 ± 22 (n-52, p<0.001)144 ± 20 (n-48, p<0.001)
Nighttime mean diastolic BP (mm Hg)90 ± 1482 ± 16 (n-21, p=0.045)83 ± 13 (n-54, p<0.001)83 ± 10 (n-52, p<0.001)83 ± 11 (n-48, p=0.102)

Office BP

Systolic BP (mm Hg)190 ± 22160 ± 23 (n-17, p<0.001)160 ± 21 (n-59, p<0.001)156 ±25 (n-62, p<0.001)162 ± 26(n-55, p<0.001)
Diastolic BP (mm Hg)107 ± 1395 ± 14 (n-17, p<0.001)91 ± 13 (n-59, p<0.001)90 ± 12 (n-62, p<0.001)94 ± 17 (n-55, p<0.001)
Office HR72 ±969 ± 12 (n-17, p=0.715)66 ± 10 (n-37, p=0.002)68 ± 11 (n-47, p=0.068)69 ± 12 (n-48, p=0.185)

Baseline24-48 hours after the procedureMonth 1Month 3Month 6Year 1

Central haemodynamics and arterial stiffness parameters

Aortic pressure65 ±1756±17 (n-58, p<0.001)54±16 (n-22, p<0.001)58±17 (n-45, p=0.001)56±19 (n-50, p<0.001)57±15 (n-45, p<0.001)
Augmentation index HR27 ±1023±11 (n-57, p=0.001)21±12 (n-22, p=0.029)24±10 (n-44, p=0.01)25±10, (n-48, p=0.358)25±10 (n-46, p=0.068)
MAP128 ± 19116 ±16 (n-58, p<0.001)117±18 (n-22, p=0.001)118±16 (n-45, p<0.001)117±23 (n-50, p=0.001)119±19 (n-46, p<0.001)
AoPWV11.3 ±2.710.3 ±2.6 (n-58, p=0.001)9.4 ±2.2 (n-22, p<0.001)10.3 ±2.9 (n-44, p=0.013)10 ±2.6 (n-48, p<0.001)10.4 ±2.7 n-45, p=0.013

BP: blood pressure; HR: heart rate; MAP: mean arterial pressure; AoPWV: aortic pulse wave velocity.