| | | Single drug class | Combination | Combination (vs. single) |
| | | | | OR (95% CI) | | Overall | 1,947,796 (66.72) | 971366 (33.28) | | | Age (mean ± SD) | 53.13 ± 14.48 | 52.84 ± 14.52 | | | <20 | 29,435 (65.09) | 15,787 (34.91) | 1.214 (1.190–1.239) | | 20–29 | 72,099 (75.51) | 23,390 (24.49) | 0.650 (0.640–0.661) | | 30–39 | 202,994 (66.88) | 100,529 (33.12) | 0.957 (0.948–0.965) | | 40–49 | 458,093 (64.2) | 255,431 (35.8) | 1.094 (1.087–1.101) | | 50–59 | 574,198 (66.28) | 292,172 (33.72) | 1 (ref.) | | 60–69 | 348,811 (68.57) | 159,851 (31.43) | 0.900 (0.894–0.907) | | 70–79 | 202,102 (68.56) | 92,669 (31.44) | 0.913 (0.905–0.922) | | ≥80 | 60,064 (65.57) | 31,537 (34.43) | 1.041 (1.026–1.057) | | Sex | | | | | Male | 1,048,973 (64.21) | 584,795 (35.79) | 1 (ref.) | | Female | 898,823 (69.93) | 386,571 (30.07) | 0.764 (0.760–0.768) | | Income | | | | | Medical aid | 75,202 (67.01) | 37,015 (32.99) | 1.133 (1.118–1.149) | | Q1(Low) | 499,304 (65.15) | 267,074 (34.85) | 1.220 (1.212–1.229) | | Q2 | 457,765 (65.71) | 238,878 (34.29) | 1.184 (1.175–1.193) | | Q3 | 444,104 (66.93) | 219,420 (33.07) | 1.115 (1.107–1.123) | | Q4(High) | 471,421 (69.29) | 208,979 (30.71) | 1 (ref.) | | Residence | | | | | Metropolitan | 1,172,041 (67.31) | 569,263 (32.69) | 1 (ref.) | | City | 549,150 (65.86) | 284,617 (34.14) | 1.068 (1.062–1.074) | | Rural | 226,605 (65.86) | 117,486 (34.14) | 1.077 (1.069–1.086) | | Charlson’s comorbidity index | | | | | 0 | 616,812 (65.75) | 321,322 (34.25) | 1.050 (1.041–1.058) | | 1 | 531,229 (67.13) | 260,159 (32.87) | 0.999 (0.992–1.007) | | 2 | 338,054 (67.95) | 159,469 (32.05) | 0.962 (0.955–0.970) | | ≥3 | 461,701 (66.71) | 230,416 (33.29) | 1 (ref.) | | Comorbidity | | | | | Diabetes | 258,962 (69.71) | 112,515 (30.29) | 0.816 (0.810–0.823) | | Dyslipidemia | 528,199 (65.51) | 278,047 (34.49) | 1.107 (1.101–1.114) | | Congestive heart failure | 65,091 (53.91) | 55,658 (46.09) | 1.890 (1.867–1.914) | | Ischemic heart failure | 257,083 (64.02) | 144,464 (35.98) | 1.132 (1.123–1.140) | | Stroke | 87,896 (64.83) | 47,673 (35.17) | 1.141 (1.128–1.155) | | Chronic kidney disease | 17,263 (63.32) | 10,000 (36.68) | 1.193 (1.163–1.224) | | Cancer | 29,331 (65.73) | 15,295 (34.27) | 1.177 (1.153–1.201) | | Provider type | | | | | General hospital | 641,364 (69.37) | 283,228 (30.63) | 0.767 (0.763–0.772) | | Hospital | 216,869 (65.53) | 114,059 (34.47) | 0.964 (0.956–0.971) | | Clinic | 1019,985 (65.35) | 540,715 (34.65) | 1 (ref.) | | Other | 69,578 (67.59) | 33,364 (32.41) | 0.900 (0.888–0.913) | | Year of diagnosis | | | | | 2011 | 402,660 (64.19) | 224,589 (35.81) | 1 (ref.) | | 2012 | 395,541 (66.15) | 202,371 (33.85) | 0.915 (0.909–0.922) | | 2013 | 395,450 (68.36) | 183,029 (31.64) | 0.824 (0.818–0.831) | | 2014 | 364,782 (67.74) | 173,686 (32.26) | 0.843 (0.837–0.850) | | 2015 | 389,363 (67.47) | 187,691 (32.53) | 0.850 (0.843–0.856) |
|
|
