Research Article

Polymorphism of MTHFR C677T Gene and the Associations with the Severity of Essential Hypertension in Northern Chinese Population

Table 5

Univariate analysis of biochemical indicators and MTHFR C677T polymorphisms in patients with hypertension.

FactorHypertension grade (%) value
Grade 1Grade 2Grade 3

TC (mmol/l)4.65 ± 1.204.44 ± 0.964.30 ± 1.010.131
TG (mmol/l)1.37 ± 0.481.76 ± 0.811.86 ± 1.050.028a
LDL-C (mmol/l)2.50 ± 0.782.41 ± 0.662.26 ± 0.810.050
ALT (U/l)22.34 ± 16.3521.37 ± 11.4523.13 ± 15.400.702
AST (U/l)21.75 ± 10.4022.65 ± 6.8523.32 ± 8.100.725
GGT (U/l)33.21 ± 17.8530.74 ± 17.3835.60 ± 19.700.069
Hcy (μmol/l)13.38 ± 5.6019.16 ± 9.7222.72 ± 14.300.000c
MTHFR C677T genotype (n) (%)
 CC21 (30.9)34 (50.0)13 (19.1)0.005b
 CT30 (20.8)30 (20.8)84 (58.4)
 TT2 (2.1)26 (27.7)66 (70.2)

abc MTHFR: methylenetetrahydrofolate reductase; TG: triglycerides; TC: total cholesterol; LDL-C: low-density lipoprotein cholesterol; ALT: alanine aminotransferase; AST: aspartate transaminase; GGT: γ-glutamyl transpeptidase.