Research Article
Polymorphism of MTHFR C677T Gene and the Associations with the Severity of Essential Hypertension in Northern Chinese Population
Table 5
Univariate analysis of biochemical indicators and MTHFR C677T polymorphisms in patients with hypertension.
| Factor | Hypertension grade (%) | value | Grade 1 | Grade 2 | Grade 3 |
| TC (mmol/l) | 4.65 ± 1.20 | 4.44 ± 0.96 | 4.30 ± 1.01 | 0.131 | TG (mmol/l) | 1.37 ± 0.48 | 1.76 ± 0.81 | 1.86 ± 1.05 | 0.028a | LDL-C (mmol/l) | 2.50 ± 0.78 | 2.41 ± 0.66 | 2.26 ± 0.81 | 0.050 | ALT (U/l) | 22.34 ± 16.35 | 21.37 ± 11.45 | 23.13 ± 15.40 | 0.702 | AST (U/l) | 21.75 ± 10.40 | 22.65 ± 6.85 | 23.32 ± 8.10 | 0.725 | GGT (U/l) | 33.21 ± 17.85 | 30.74 ± 17.38 | 35.60 ± 19.70 | 0.069 | Hcy (μmol/l) | 13.38 ± 5.60 | 19.16 ± 9.72 | 22.72 ± 14.30 | 0.000c | MTHFR C677T genotype (n) (%) | | | | | CC | 21 (30.9) | 34 (50.0) | 13 (19.1) | 0.005b | CT | 30 (20.8) | 30 (20.8) | 84 (58.4) | TT | 2 (2.1) | 26 (27.7) | 66 (70.2) |
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abc MTHFR: methylenetetrahydrofolate reductase; TG: triglycerides; TC: total cholesterol; LDL-C: low-density lipoprotein cholesterol; ALT: alanine aminotransferase; AST: aspartate transaminase; GGT: γ-glutamyl transpeptidase. |