Magnesium Lithospermate B Downregulates the Levels of Blood Pressure, Inflammation, and Oxidative Stress in Pregnant Rats with Hypertension

Figure 2

MLB inhibited generation of inflammatory cytokines. (a) The levels of TNF-α, IL-1β, IL-6, and MCP-1 in serum of rats (n = 10). (b) The levels of TNF-α, IL-1β, IL-6, and MCP-1 in placentas of rats (n = 10).  < 0.001 vs. control.  < 0.01 and  < 0.001 vs. PIH.  < 0.01 and  < 0.001 vs. MLB 5 mg/kg. MLB, magnesium lithospermate B; PIH, pregnancy-induced hypertension; TNF-α, tumor necrosis factor-α; IL, interleukin; MCP, monocyte chemotactic protein.

(a)

(b)