International Journal of Hypertension

Research Article

The Association between Gly460Trp-Polymorphism of Alpha-Adducin 1 Gene (ADD1) and Arterial Hypertension Development in Ukrainian Population

Table 4

Analysis of the ADD1 rs4961-polymorphism association with arterial hypertension occurrence.


Model of inheritance	P_c	OR_c (95% CI)	P_a¹	OR_a (95% CI)

Dominant	0.024	2.231 (1.109–4.487)	0.046 (0.261)	2.138 (1.014–4.509)
Recessive	0.368	2.846 (0.292–27.711)	0.475 (0.541)	2.32 (0.23–23.413)
Overdominant	0.043	2.106 (1.022–4.341)	0.072 (0.352)	2.023 (0.939–4.359)
Additive^а	0.038	2.154 (1.044–4.444)	0.061 (0.299)	2.087 (0.966–4.51)
Additive^а	0.314	3.231 (0.33–31.621)	0.349 (0.441)	3.034 (0.297–30.993)

P_c: crude value; OR_c: crude odds ratio; P_a: value adjusted for age, BMI, and smoking habit; OR_a: odds ratio adjusted for age, BMI, and smoking habit; 95% CI: 95% confidence interval. a: upper row: comparison between GT and TT genotypes; lower row: comparison between TT and GG genotypes. 1: value adjusted for sex is shown in parentheses.