International Journal of Hypertension

Research Article

The Association between Gly460Trp-Polymorphism of Alpha-Adducin 1 Gene (ADD1) and Arterial Hypertension Development in Ukrainian Population

Table 7

Analysis of the association between ADD1 rs4961-polymorphism and arterial hypertension occurrence according to BMI.


Model of inheritance¹	P_c	OR_c (95% CI)	P_c^int	P_a³	OR_a (95% CI)	P_a^int3

Dominant	0.556	0.682 (0.191–2.433)	0.017	0.407 (0.39)	0.564 (0.145–2.186)	0.027 (0.077)
	0.001	4.408 (1.859–10.454)		0.006 (0.063)	3.527 (1.442–8.625)

Overdominant	0.556	0.682 (0.191–2.433)	0.025	0.405 (0.387)	0.561 (0.144–2.185)	0.032 (0.092)
	0.002	4.07 (1.649–10.046)		0.001 (0.094)	3.418 (1.342–8.704)

Additive²	0.556	0.682 (0.191–2.433)	0.021	0.407 (0.392)	0.564 (0.145–2.187)	0.028 (0.079)
	0.002	4.312 (1.74–10.689)		0.008 (0.072)	3.582 (1.402–9.154)

P_c: crude value; OR_c crude odds ratio; P_c^intcrude value interaction terms; P_a value adjusted for age and smoking habit; OR_aodds ratio adjusted for age and smoking habit; P_a^int value interaction terms adjusted for covariates; 95% CI 95% confidence interval. 1upper rowresults for BMI < 25 kg/m²; lower rowfor BMI ≥25 kg/m². 2: upper row: comparison between GT and TT genotypes; lower row: comparison between TT and GG genotypes. 3 value adjusted for sex is shown in parentheses.