Despite the availability of efficient antihypertensive drugs, blood pressure control rates are not satisfactory in hypertensive patients all over the world. The association of hypertension with other criteria for metabolic syndrome, such as an elevated waist circumference, fasting glucose and triglycerides, and reduced HDL-cholesterol levels, seems to contribute to the failure of treatment efficacy. Furthermore, these metabolic risk factors are also associated to adverse cardiovascular outcomes, especially in the presence of some cardiac risk markers including family history of premature myocardial infarction or stroke, microalbuminuria, and elevated C-reactive protein among others. The relationship between hypertension and several vascular and metabolic abnormalities, characterizing the cardiometabolic syndrome, is the main subject of this special issue. Potential topics include, but are not limited to:

• The role of inflammation and oxidative stress in hypertension
• Pathophysiological alterations induced by metabolic risk factors
• Obesity, abdominal fat, and hypertension
• New evidences about insulin resistance, diabetes, and hypertension
• The impact of dyslipidemia in hypertensive patients
• Relevance of hypertension in metabolic syndrome
• Mechanisms of left ventricular hypertrophy in obesity
• Assessment of cardiovascular risk in hypertensive patients
• Effects of metabolic risk factors on microcirculation
• Early manifestations of atherosclerosis accelerated by metabolic factors: endothelial dysfunction, increased vascular stiffness, and carotid intima-media thickening
• Nutritional approach of metabolic factors in hypertension
• Effects of antihypertensive and oral hypoglycemic drugs, statins, and other hypolipidemic agents

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