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International Journal of Inflammation
Volume 2010 (2010), Article ID 514659, 5 pages
Research Article

Salivary C-Reactive Protein in Hashimoto's Thyroiditis and Subacute Thyroiditis

1Department of Biochemistry, Yenepoya Medical College, Deralakatte, Mangalore 575018, India
2Department of Biochemistry, K. S. Hegde Medical Academy, Deralakatte, Mangalore 575018, India
3Department of Pathology, Yenepoya Medical College, Deralakatte, Mangalore 575018, India
4Department of Biochemistry, A. J. Institute of Medical Sciences, Mangalore 575004, India

Received 16 June 2010; Revised 13 August 2010; Accepted 23 August 2010

Academic Editor: Andrew Stewart Day

Copyright © 2010 Nivedita L. Rao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


C-reactive protein (CRP), an acute-phase reactant, has been identified as a saliva-based biomarker of inflammation. The objective of the study was to estimate and compare salivary CRP levels in Hashimoto's thyroiditis (HT) and Subacute thyroiditis (SAT). The study included 30 HT patients who presented with clinical features of hypothyroidism, 15 SAT patients who presented with clinical features of hyperthyroidism, and 20 healthy age- and sex-matched euthyroid controls. CRP levels in saliva were estimated using an Enzyme-Linked Immunosorbent Assay method with enhanced sensitivity. In HT, the mean salivary CRP levels did not differ significantly from controls. SAT patients had significantly elevated salivary CRP levels compared to HT patients and controls. The rise in salivary CRP levels in SAT patients conceivably reflects the presence of an inflammatory process. Saliva CRP levels appear to serve as inflammatory markers in SAT patients and may aid their clinical evaluation.