Table of Contents Author Guidelines Submit a Manuscript
International Journal of Inflammation
Volume 2011, Article ID 176412, 10 pages
http://dx.doi.org/10.4061/2011/176412
Research Article

Gene Profiling of Aortic Valve Interstitial Cells under Elevated Pressure Conditions: Modulation of Inflammatory Gene Networks

1Department of Agricultural and Biological Engineering, Mississippi State University, Mississippi State, MS 39762, USA
2Life Science and Biotechnology Institute, Mississippi State University, Mississippi State, MS 39762, USA
3Department of Basic Sciences, Mississippi State University, Mississippi State, MS 39762, USA
4Department of Animal Sciences, Purdue University, West Lafayette, IN 47907, USA

Received 7 March 2011; Revised 6 June 2011; Accepted 16 June 2011

Academic Editor: Adrian Chester

Copyright © 2011 James N. Warnock et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. Y. Bossé, P. Mathieu, and P. Pibarot, “Genomics: the next step to elucidate the etiology of calcific aortic valve stenosis,” Journal of the American College of Cardiology, vol. 51, no. 14, pp. 1327–1336, 2008. View at Publisher · View at Google Scholar · View at Scopus
  2. J. T. Butcher, C. A. Simmons, and J. N. Warnock, “Mechanobiology of the aortic heart valve,” Journal of Heart Valve Disease, vol. 17, no. 1, pp. 62–73, 2008. View at Google Scholar · View at Scopus
  3. C. M. Otto, B. K. Lind, D. W. Kitzman, B. J. Gersh, and D. S. Siscovick, “Association of aortic-valve sclerosis with cardiovascular mortality and morbidity in the elderly,” The New England Journal of Medicine, vol. 341, no. 3, pp. 142–147, 1999. View at Publisher · View at Google Scholar · View at Scopus
  4. N. M. Rajamannan, B. Gersh, and R. O. Bonow, “Calcific aortic stenosis: from bench to the bedside—emerging clinical and cellular concepts,” Heart, vol. 89, no. 7, pp. 801–805, 2003. View at Google Scholar · View at Scopus
  5. J. Ross Jr. and E. Braunwald, “Aortic stenosis,” Circulation, vol. 38, no. 1, pp. 61–67, 1968. View at Google Scholar · View at Scopus
  6. P. J. Cawley and C. M. Otto, “Prevention of calcific aortic valve stenosis—fact or fiction?” Annals of Medicine, vol. 41, no. 2, pp. 100–108, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. L. A. Cuniberti, P. G. Stutzbach, E. Guevara, G. G. Yannarelli, R. P. Laguens, and R. R. Favaloro, “Development of mild aortic valve stenosis in a rabbit model of hypertension,” Journal of the American College of Cardiology, vol. 47, no. 11, pp. 2303–2309, 2006. View at Publisher · View at Google Scholar · View at Scopus
  8. M. O. Platt, Y. Xing, H. Jo, and A. P. Yoganathan, “Cyclic pressure and shear stress regulate matrix metalloproteinases and cathepsin activity in porcine aortic valves,” Journal of Heart Valve Disease, vol. 15, no. 5, pp. 622–629, 2006. View at Google Scholar · View at Scopus
  9. J. N. Warnock, S. C. Burgess, A. Shack, and A. P. Yoganathan, “Differential immediate-early gene responses to elevated pressure in porcine aortic valve interstitial cells,” Journal of Heart Valve Disease, vol. 15, no. 1, pp. 34–41, 2006. View at Google Scholar · View at Scopus
  10. Y. Xing, Z. He, J. N. Warnock, S. L. Hilbert, and A. P. Yoganathan, “Effects of constant static pressure on the biological properties of porcine aortic valve leaflets,” Annals of Biomedical Engineering, vol. 32, no. 4, pp. 555–562, 2004. View at Publisher · View at Google Scholar · View at Scopus
  11. Y. Xing, J. N. Warnock, Z. He, S. L. Hilbert, and A. P. Yoganathan, “Cyclic pressure affects the biological properties of porcine aortic valve leaflets in a magnitude and frequency dependent manner,” Annals of Biomedical Engineering, vol. 32, no. 11, pp. 1461–1470, 2004. View at Publisher · View at Google Scholar · View at Scopus
  12. W. D. Merryman, I. Youn, H. D. Lukoff et al., “Correlation between heart valve interstitial cell stiffness and transvalvular pressure: implications for collagen biosynthesis,” American Journal of Physiology—Heart and Circulatory Physiology, vol. 290, no. 1, pp. H224–H231, 2006. View at Publisher · View at Google Scholar · View at Scopus
  13. N. M. Rajamannan, R. O. Bonow, and S. H. Rahimtoola, “Calcific aortic stenosis: an update,” Nature Clinical Practice Cardiovascular Medicine, vol. 4, no. 5, pp. 254–262, 2007. View at Publisher · View at Google Scholar · View at Scopus
  14. N. Côté, P. Pibarot, A. Pépin et al., “Oxidized low-density lipoprotein, angiotensin II and increased waist cirumference are associated with valve inflammation in prehypertensive patients with aortic stenosis,” International Journal of Cardiology, vol. 145, no. 3, pp. 444–449, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. J. J. Kaden, C. E. Dempfle, R. Grobholz et al., “Inflammatory regulation of extracellular matrix remodeling in calcific aortic valve stenosis,” Cardiovascular Pathology, vol. 14, no. 2, pp. 80–87, 2005. View at Publisher · View at Google Scholar
  16. K. D. O'Brien, “Pathogenesis of calcific aortic valve disease: a disease process comes of age (and a good deal more),” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 26, no. 8, pp. 1721–1728, 2006. View at Publisher · View at Google Scholar · View at Scopus
  17. C. H. Yap, H. S. Kim, K. Balachandran, M. Weiler, R. Haj-Ali, and A. P. Yoganathan, “Dynamic deformation characteristics of porcine aortic valve leaflet under normal and hypertensive conditions,” American Journal of Physiology—Heart and Circulatory Physiology, vol. 298, no. 2, pp. H395–H405, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. W. M. Muir, G. J. M. Rosa, B. R. Pittendrigh et al., “A mixture model approach for the analysis of small exploratory microarray experiments,” Computational Statistics and Data Analysis, vol. 53, no. 5, pp. 1566–1576, 2009. View at Publisher · View at Google Scholar · View at Scopus
  19. H. Akaike, “A new look at the statistical model identification,” IEEE Transactions on Automatic Control, vol. 19, no. 6, pp. 716–723, 1974. View at Google Scholar · View at Scopus
  20. G. Schwarz, “Estimating the dimension of a model,” Annals of Statisitcs, vol. 6, pp. 461–464, 1978. View at Google Scholar
  21. S. Haider, B. Ballester, D. Smedley, J. Zhang, P. Rice, and A. Kasprzyk, “BioMart central portal—unified access to biological data,” Nucleic Acids Research, vol. 37, no. 2, pp. W23–W27, 2009. View at Publisher · View at Google Scholar · View at Scopus
  22. D. Peddinti, B. Nanduri, A. Kaya, J. M. Feugang, S. C. Burgess, and E. Memili, “Comprehensive proteomic analysis of bovine spermatozoa of varying fertility rates and identification of biomarkers associated with fertility,” BioMed Central Systems Biology, vol. 2, no. 1, p. 19, 2008. View at Publisher · View at Google Scholar · View at Scopus
  23. S. A. Dreger, P. M. Taylor, S. P. Allen, and M. H. Yacoub, “Profile and localization of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) in human heart valves,” Journal of Heart Valve Disease, vol. 11, no. 6, pp. 875–880, 2002. View at Google Scholar · View at Scopus
  24. M. E. Edep, J. Shirani, P. Wolf, and D. L. Brown, “Matrix metalloproteinase expression in nonrheumatic aortic stenosis,” Cardiovascular Pathology, vol. 9, no. 5, pp. 281–286, 2000. View at Publisher · View at Google Scholar · View at Scopus
  25. K. Akat, M. Borggrefe, and J. J. Kaden, “Aortic valve calcification: basic science to clinical practice,” Heart, vol. 95, no. 8, pp. 616–623, 2009. View at Publisher · View at Google Scholar · View at Scopus
  26. J. J. Kaden, C. E. Dempfle, R. Grobholz et al., “Interleukin-1 beta promotes matrix metalloproteinase expression and cell proliferation in calcific aortic valve stenosis,” Atherosclerosis, vol. 170, no. 2, pp. 205–211, 2003. View at Publisher · View at Google Scholar · View at Scopus
  27. V. J. Dzau, R. C. Braun-Dullaeus, and D. G. Sedding, “Vascular proliferation and atherosclerosis: new perspectives and therapeutic strategies,” Nature Medicine, vol. 8, no. 11, pp. 1249–1256, 2002. View at Publisher · View at Google Scholar · View at Scopus
  28. Y. Naito, T. Tsujino, H. Akahori et al., “Increase in tissue and circulating pentraxin3 levels in patients with aortic valve stenosis,” American Heart Journal, vol. 160, no. 4, pp. 685–691, 2010. View at Publisher · View at Google Scholar · View at Scopus
  29. M. Nebuloni, F. Pasqualini, P. Zerbi et al., “PTX3 expression in the heart tissues of patients with myocardial infarction and infectious myocarditis,” Cardiovascular Pathology, vol. 20, no. 1, pp. e27–e35, 2011. View at Publisher · View at Google Scholar
  30. M. Salio, S. Chimenti, N. D. Angelis et al., “Cardioprotective function of the long pentraxin PTX3 in acute myocardial infarction,” Circulation, vol. 117, no. 8, pp. 1055–1064, 2008. View at Publisher · View at Google Scholar · View at Scopus