Review Article

Definition of Nonresponse to Analgesic Treatment of Arthritic Pain: An Analytical Literature Review of the Smallest Detectable Difference, the Minimal Detectable Change, and the Minimal Clinically Important Difference on the Pain Visual Analog Scale

Figure 1

Minimal detectable change by baseline pain score, for different values of the reliability coefficient. Closed symbols show data for rheumatoid arthritis, while open symbols depict osteoarthritis. Squares show MDC at RC = 0.75, diamonds at RC = 0.85, and triangles at RC = 0.95.
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