International Journal of Inflammation / 2011 / Article / Fig 1

Research Article

Cytotoxicity and Induction of Inflammation by Pepsin in Acid in Bronchial Epithelial Cells

Figure 1

Exposure of cells for 5 minutes induced more cytotoxicity as measured by LDH after 20 hours incubation at pH 2.0 (mean (SEM) 57%  ± 5.77%) compared to both pH 1.5 and pH 2.5 (22%  ± 2.17%, and 28%  ± 2.81%, resp., both ). LDH release was pH-dependent ( ). There was a trend for a pepsin effect ( ), with lower LDH release with pepsin at all concentrations compared to no pepsin, independent of pH levels.

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