Research Article

Modelling Cost-Effectiveness of Biologic Treatments Based on Disease Activity Scores for the Management of Rheumatoid Arthritis in Spain

Table 2

Estimated biological treatment costs.

Biological therapies Year 1 Year 2

Abatacept (250 mg vial)1st 6 months2nd 6 months1st 6 months2nd 6 months
 Estimated number of vials per year37.835.1
 Infusion cost/IV infusion56.69 €56.69 €
 Estimated reimbursement cost per year13,449.86 €12,489.15 €
Estimated cost per six months (26 weeks)6,724.93 €6,724.93 €5,764.22 €6,724.93 €

Adalimumab (40 mg syringe)1st 6 months2nd 6 months1st 6 months2nd 6 months
 Estimated number of prefilled syringes per year2626
 Estimated reimbursement cost per year13,367.77 €13,367.77 €
Estimated cost per six months (26 weeks)6,683.89 €6,683.89 €6,683.89 €6,683.89 €

Etanercept (25 mg vial)1st 6 months2nd 6 months1st 6 months2nd 6 months
 Estimated number of vials per year104104
 Estimated reimbursement cost per year12,313.86 €12,313.86 €
Estimated cost per six months (26 weeks)6,156.93 €6,156.93 €6,156.93 €6,156.93 €

Infliximab (100 mg vial)1st 6 months2nd 6 months1st 6 months2nd 6 months
 Estimated number of vials per year11.58.18.88.8
 Infusion cost/IV infusion56.69 €56.69 €
 Estimated reimbursement cost per year10,966.75 €9,794.14 €
Estimated cost per six months (26 weeks)6,446.38 €4,520.37 €4,897.07 €4,897.07 €

Rituximab (500 mg vial)1st 6 months2nd 6 months1st 6 months2nd 6 months
 Estimated number of vials per year8.008.00
 Infusion cost/IV infusion56.69 €56.69 €
 Estimated reimbursement cost per year10,202.76 €10,202.76 €
Estimated cost per six months (26 weeks)5,101.38 €5,101.38 €5,101.38 €5,101.38 €

Based on 2008 acquisition costs and recommended dosing.